Incidence, mortality and survival rates of lip, oral cavity and salivary glands cancers in Singapore: A half-century time trend analysis (1968–2017)

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Community dentistry and oral epidemiology Pub Date : 2024-03-10 DOI:10.1111/cdoe.12951

Marco A. Peres, Huihua Li, Gustavo G. Nascimento, Fabio R. M. Leite

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引用次数: 0

Abstract

Objectives

To examine trends in incidence and mortality and evaluate overall survival (OS) of oral cancer in Singapore between 1968 and 2017.

Methods

All diagnosed oral cancers by anatomical sites and population size were extracted from the Singapore Cancer Registry and the Department of Statistics Singapore. The trend of age-standardized incidence rate (ASIR) and mortality rate (ASMR) (per 100 000 person-years) of the lip, oral cavity and salivary gland cancers were evaluated by Prais-Winsten regressions for each ethnicity and gender. Kaplan–Meier curves were performed to evaluate the OS by anatomical sites in each age group by ethnicity and sex.

Results

Overall, 49, 3494 and 1066 people were diagnosed, and 28, 2310 and 476 died from lip, oral cavity and salivary gland cancers, respectively. The oral cavity cancer ASIR and ASMR reduced from 3.07 (1968–1972) to 2.01(2008–2012) and from 2.06 (1978–1982) to 1.21 (2013–2017) per 100 000 person-years, respectively, with both highest in Indians throughout the whole period. Male:Female ratio ranged from 3.43 (1973–1977) to 1.75 (2013–2017) and from 3.41 (1978–1982) to 2.40 (2013–2017) for ASIR and ASMR, respectively. However, both salivary gland cancer ASIR and ASMR increased from 0.50 (1968–1972) to 0.80 (2008–2012) and from 0.18 (1968–1982) to 0.42 (1988–1992) per 100 000 person-years, respectively, with both higher in males since 1993. Oral cavity cancer ASIR decreased for males aged ≥60, and Indian females ≥25, but increased among Chinese females aged ≥60. Oral cavity cancer ASMR decreased among Chinese aged 25–59, and among Malay males and Indian females. Salivary gland cancer ASIR increased among Chinese males aged ≥60 and Malay males aged 25–59; while ASMR increased among Chinese males aged ≥60. The median OS for oral cavity, lip and salivary gland cancers were 3.0, 9.3 and 18.1 years, respectively, with females surviving longer than males.

Conclusions

Singapore has experienced a decline in the incidence and mortality of lip, oral cancer, an increase in in the incidence and mortality of salivary gland cancer, with an increase in the median overall survival rate. Monitoring the magnitude of oral cancer burden and the demographic, and temporal variations is necessary for tailoring health planning and setting priorities for future clinical care and research.

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新加坡唇癌、口腔癌和唾液腺癌的发病率、死亡率和存活率：半个世纪的时间趋势分析（1968-2017 年）。

目的研究1968年至2017年间新加坡口腔癌的发病率和死亡率趋势，并评估总体生存率（OS）：方法：从新加坡癌症登记处和新加坡统计局提取按解剖部位和人口规模划分的所有确诊口腔癌数据。通过Prais-Winsten回归评估了每个种族和性别的唇癌、口腔癌和唾液腺癌的年龄标准化发病率（ASIR）和死亡率（ASMR）（每十万人年）的趋势。通过卡普兰-梅耶曲线评估了不同种族和性别各年龄组解剖部位的 OS：结果：总体而言，49、3494 和 1066 人确诊为唇癌、口腔癌和唾液腺癌，分别有 28、2310 和 476 人死亡。口腔癌ASIR和ASMR分别从每10万人年3.07例（1968-1972年）降至2.01例（2008-2012年），从每10万人年2.06例（1978-1982年）降至1.21例（2013-2017年），在整个期间，印度人的ASIR和ASMR最高。涎腺癌死亡率和涎腺癌死亡率的男女比例分别为 3.43（1973-1977 年）至 1.75（2013-2017 年）和 3.41（1978-1982 年）至 2.40（2013-2017 年）。然而，唾液腺癌症的 ASIR 和 ASMR 分别从每 100 000 人年 0.50 例（1968-1972 年）上升至 0.80 例（2008-2012 年），以及从每 100 000 人年 0.18 例（1968-1982 年）上升至 0.42 例（1988-1992 年），自 1993 年以来，男性的 ASIR 和 ASMR 均有所上升。口腔癌 ASIR 在年龄≥60 岁的男性和年龄≥25 岁的印度女性中有所下降，但在年龄≥60 岁的中国女性中有所上升。口腔癌 ASMR 在 25-59 岁的华人、马来男性和印度女性中有所下降。唾液腺癌的 ASIR 在年龄≥60 岁的华人男性和 25-59 岁的马来男性中有所增加；而 ASMR 在年龄≥60 岁的华人男性中有所增加。口腔癌、唇癌和唾液腺癌的中位生存期分别为3.0年、9.3年和18.1年，女性的生存期长于男性：结论：新加坡的唇癌和口腔癌发病率和死亡率有所下降，唾液腺癌发病率和死亡率有所上升，总体生存率中位数有所提高。监测口腔癌负担的严重程度以及人口和时间上的变化，对于制定健康规划和确定未来临床护理和研究的优先事项十分必要。

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来源期刊

Community dentistry and oral epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.40

自引率

8.70%

发文量

审稿时长

6 months

期刊介绍： The aim of Community Dentistry and Oral Epidemiology is to serve as a forum for scientifically based information in community dentistry, with the intention of continually expanding the knowledge base in the field. The scope is therefore broad, ranging from original studies in epidemiology, behavioral sciences related to dentistry, and health services research through to methodological reports in program planning, implementation and evaluation. Reports dealing with people of all age groups are welcome. The journal encourages manuscripts which present methodologically detailed scientific research findings from original data collection or analysis of existing databases. Preference is given to new findings. Confirmations of previous findings can be of value, but the journal seeks to avoid needless repetition. It also encourages thoughtful, provocative commentaries on subjects ranging from research methods to public policies. Purely descriptive reports are not encouraged, nor are behavioral science reports with only marginal application to dentistry. The journal is published bimonthly.