Preparation, Investigation of Physicochemical Properties and Stability of Azelaic Acid Gel Formulation

Abstract

Background Rosacea as a skin inflammatory disease may be triggered by some types of bacteria. Azelaic acid with antibacterial property can be used for treatment of skin conditions such as Rosacea. Objective In this study, we aim to prepare and evaluate the physicochemical properties and primary stability of 15% azelaic acid gel. Methods For the gel preparation, first, an aqueous solution containing ethylenediaminetetraacetic and benzoic acids was prepared. Then, a mixture of polysorbate 80 and triglyceride was added to the solution at 50°C. Then, lecithin, propylene glycol, and carbomer 940 P was added to the mixture, and stirred. After that, the gel was prepared. Then, 15 g of dissolved azelaic acid in propylene glycol was added to the gel. Finally, the formulation was homogenized for 15 min. Results