Recent advances in the synthesis of C-Aryl-glycosides since 2019

Synlett Pub Date : 2024-03-07 DOI:10.1055/a-2283-0623
Jiagen Li, Xuefeng Jiang
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Abstract

C-Aryl-glycosides represent a significant subclass of crucial glycosidic compounds, increasingly capturing the attention of pharmaceutical developers as bioelectronic motifs embedded within glycosides. Their outstanding resistance to enzymatic hydrolysis bestows a distinctive advantage in the field of drug development, particularly in therapeutic domains such as diabetes treatment, where pharmaceuticals based on the C-Aryl-glycosides architecture manifest compelling therapeutic efficacy. As a result, researchers in the realm of synthetic chemistry have diligently explored and devised a plethora of streamlined and efficacious synthetic methodologies. This comprehensive review systematically delineates methodologies employed in recent years for the efficient synthesis of C-Aryl-glycosides, offering insights into three primary directions: transition metal catalysis, radical strategies, and metal-free catalysis process.

Abstract Image

2019 年以来 C-芳基苷合成的最新进展
C-Aryl 糖苷是重要糖苷化合物的一个重要亚类,作为嵌入糖苷中的生物电子基团,它越来越受到药物开发人员的关注。它们出色的抗酶水解性使其在药物开发领域具有独特的优势,尤其是在糖尿病治疗等治疗领域,基于 C-丙烯酰糖苷结构的药物具有显著的疗效。因此,合成化学领域的研究人员孜孜不倦地探索并设计出了大量精简而有效的合成方法。本综述系统地阐述了近年来用于高效合成 C-丙烯酰糖苷的方法,并对以下三个主要方向提出了见解:过渡金属催化、自由基策略和无金属催化过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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