{"title":"Recent advances in the synthesis of C-Aryl-glycosides since 2019","authors":"Jiagen Li, Xuefeng Jiang","doi":"10.1055/a-2283-0623","DOIUrl":null,"url":null,"abstract":"C-Aryl-glycosides represent a significant subclass of crucial glycosidic compounds, increasingly capturing the attention of pharmaceutical developers as bioelectronic motifs embedded within glycosides. Their outstanding resistance to enzymatic hydrolysis bestows a distinctive advantage in the field of drug development, particularly in therapeutic domains such as diabetes treatment, where pharmaceuticals based on the C-Aryl-glycosides architecture manifest compelling therapeutic efficacy. As a result, researchers in the realm of synthetic chemistry have diligently explored and devised a plethora of streamlined and efficacious synthetic methodologies. This comprehensive review systematically delineates methodologies employed in recent years for the efficient synthesis of C-Aryl-glycosides, offering insights into three primary directions: transition metal catalysis, radical strategies, and metal-free catalysis process.","PeriodicalId":509029,"journal":{"name":"Synlett","volume":"5 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synlett","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2283-0623","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
C-Aryl-glycosides represent a significant subclass of crucial glycosidic compounds, increasingly capturing the attention of pharmaceutical developers as bioelectronic motifs embedded within glycosides. Their outstanding resistance to enzymatic hydrolysis bestows a distinctive advantage in the field of drug development, particularly in therapeutic domains such as diabetes treatment, where pharmaceuticals based on the C-Aryl-glycosides architecture manifest compelling therapeutic efficacy. As a result, researchers in the realm of synthetic chemistry have diligently explored and devised a plethora of streamlined and efficacious synthetic methodologies. This comprehensive review systematically delineates methodologies employed in recent years for the efficient synthesis of C-Aryl-glycosides, offering insights into three primary directions: transition metal catalysis, radical strategies, and metal-free catalysis process.