Synthesis, Characterization, and Biological Evaluation of New Cyclic Quinazoline Derivatives as Potential Antibacterial and Antifungal Agents

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Doklady Chemistry Pub Date : 2024-03-08 DOI:10.1134/S0012500823600554

Oday H. R. Al-Jeilawi, Safaa H. F. Tuama, Iftikhar A. Hussein, Andy N. S. Shamaya

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Abstract

Heterocyclic compounds are crucial for medicinal chemistry and the development of therapeutic agents like broad-spectrum antibiotics. This study devised a facile procedure to synthesize novel antimicrobial bicyclic heterocycles from 2-mercapto-3-phenylquinazolin-4(3H)-one. Advanced analytical techniques including ¹H and ¹³C NMR, elemental analysis, and FT-IR spectroscopy characterized the intricate chemical structures of the products. In vitro assays tested the heterocycles against aerobic and anaerobic bacterial strains using fluconazole and ciprofloxacin as antifungal and antibacterial controls. Results demonstrated the formidable broad-spectrum antibacterial and antifungal activities of the synthesized compounds, with growth inhibition approaching that of the positive controls. These findings highlight the immense potential of these novel heterocyclic compounds as antimicrobial agents. Further research can optimize their drug-like properties for eventual clinical use in combating drug-resistant infections.

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作为潜在抗菌剂和抗真菌剂的新型环状喹唑啉衍生物的合成、表征和生物学评价

摘要杂环化合物对于药物化学和广谱抗生素等治疗药物的开发至关重要。本研究设计了一种简便的程序，从 2-巯基-3-苯基喹唑啉-4(3H)-酮合成新型抗菌双环杂环化合物。先进的分析技术，包括 1H 和 13C NMR、元素分析和傅立叶变换红外光谱，对产品复杂的化学结构进行了表征。体外试验以氟康唑和环丙沙星作为抗真菌和抗菌对照，测试了这些杂环化合物对需氧和厌氧细菌菌株的作用。结果表明，合成的化合物具有强大的广谱抗菌和抗真菌活性，对生长的抑制作用接近阳性对照组。这些发现凸显了这些新型杂环化合物作为抗菌剂的巨大潜力。进一步的研究可以优化这些化合物的类药物特性，最终用于临床抗耐药性感染。

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来源期刊

Doklady Chemistry 化学-化学综合

CiteScore

1.20

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.