Passive-Flow-Based MPS: Emerging Physiological Flow-Mimetic Platforms for Studying Effects of Flow on Single Tissues and Inter-tissue Interactions

IF 5.5 3区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Geonho Jin, Dohyung Kim, Seonghun Mun, Seokyoung Bang
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Abstract

Flow at various scales, such as perfusion flow and interstitial flow, is a critical component of the physiology of living systems. Microphysiological system (MPS), which is designed to mimic human physiology, needs to recapitulate various physiological flows to accurately reflect in vivo conditions. Most MPSs that simulate flows utilize a pump and tubing (pumped-based-flow MPS). However, these components have limitations that prevent them from recapitulating sophisticated physiological phenomena. Alternatively, passive-flow MPS can be used to recapitulate physiological flow on various scales without using pumps or tubing. This review presents recent developments in passive-flow-based MPS using various engineering approaches. To this end, engineering approaches that enable a passive-flow-based MPS to operate are summarized. Subsequently, representative examples of passive-flow-based MPS are reviewed under the criterion of whether they can recapitulate single-organ (tissue) or multi-organ (tissue) systems. It is our belief that passive-flow-based MPS will be widely used in a wide range of fields, such as human physiology research, analysis of pharmacokinetics and pharmacodynamics (PK/PD), and even space medicine research.

Abstract Image

基于被动流的 MPS:研究流动对单个组织和组织间相互作用影响的新兴生理流动模拟平台
各种尺度的流动,如灌注流和间隙流,是生命系统生理学的重要组成部分。微生理系统(MPS)旨在模拟人体生理,需要再现各种生理流动,以准确反映体内情况。大多数模拟流动的 MPS 都使用泵和管道(基于泵的流动 MPS)。然而,这些组件有其局限性,无法再现复杂的生理现象。另外,被动流式 MPS 无需使用泵或管道,也可用于再现各种规模的生理流动。本综述介绍了采用各种工程方法的被动流式 MPS 的最新进展。为此,总结了使基于被动流的 MPS 能够运行的工程方法。随后,根据被动流式 MPS 是否能再现单器官(组织)或多器官(组织)系统的标准,对具有代表性的被动流式 MPS 进行了综述。我们相信,基于被动流的 MPS 将广泛应用于各种领域,如人体生理学研究、药动学和药效学(PK/PD)分析,甚至太空医学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioChip Journal
BioChip Journal 生物-生化研究方法
CiteScore
7.70
自引率
16.30%
发文量
47
审稿时长
6-12 weeks
期刊介绍: BioChip Journal publishes original research and reviews in all areas of the biochip technology in the following disciplines, including protein chip, DNA chip, cell chip, lab-on-a-chip, bio-MEMS, biosensor, micro/nano mechanics, microfluidics, high-throughput screening technology, medical science, genomics, proteomics, bioinformatics, medical diagnostics, environmental monitoring and micro/nanotechnology. The Journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.
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