LncRNAs act as modulators of macrophages within the tumor microenvironment.

IF 3.3 3区 医学 Q2 ONCOLOGY
Kangning Li, Tao Xie, Yong Li, Xuan Huang
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引用次数: 0

Abstract

Long non-coding RNAs (lncRNAs) have been established as pivotal players in various cellular processes, encompassing the regulation of transcription, translation and post-translational modulation of proteins, thereby influencing cellular functions. Notably, lncRNAs exert a regulatory influence on diverse biological processes, particularly in the context of tumor development. Tumor-associated macrophages (TAMs) exhibit the M2 phenotype, exerting significant impact on crucial processes such as tumor initiation, angiogenesis, metastasis and immune evasion. Elevated infiltration of TAMs into the tumor microenvironment (TME) is closely associated with a poor prognosis in various cancers. LncRNAs within TAMs play a direct role in regulating cellular processes. Functioning as integral components of tumor-derived exosomes, lncRNAs prompt the M2-like polarization of macrophages. Concurrently, reports indicate that lncRNAs in tumor cells contribute to the expression and release of molecules that modulate TAMs within the TME. These actions of lncRNAs induce the recruitment, infiltration and M2 polarization of TAMs, thereby providing critical support for tumor development. In this review, we survey recent studies elucidating the impact of lncRNAs on macrophage recruitment, polarization and function across different types of cancers.

LncRNA 是肿瘤微环境中巨噬细胞的调节因子。
长非编码 RNA(lncRNA)在各种细胞过程中发挥着关键作用,包括调控转录、翻译和蛋白质翻译后调节,从而影响细胞功能。值得注意的是,lncRNAs 对多种生物过程具有调控作用,尤其是在肿瘤发生发展过程中。肿瘤相关巨噬细胞(TAMs)表现出 M2 表型,对肿瘤的发生、血管生成、转移和免疫逃避等关键过程产生重要影响。TAMs 在肿瘤微环境(TME)中的浸润增加与各种癌症的不良预后密切相关。TAMs 中的 LncRNA 在调节细胞过程中发挥着直接作用。作为肿瘤外泌体的组成部分,lncRNAs能促使巨噬细胞M2样极化。同时,有报告表明,肿瘤细胞中的lncRNAs有助于表达和释放调节TME内TAMs的分子。lncRNAs的这些作用诱导了TAMs的招募、浸润和M2极化,从而为肿瘤的发展提供了关键的支持。在这篇综述中,我们调查了最近的一些研究,这些研究阐明了lncRNAs对不同类型癌症中巨噬细胞的招募、极化和功能的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Carcinogenesis
Carcinogenesis 医学-肿瘤学
CiteScore
9.20
自引率
2.10%
发文量
95
审稿时长
1 months
期刊介绍: Carcinogenesis: Integrative Cancer Research is a multi-disciplinary journal that brings together all the varied aspects of research that will ultimately lead to the prevention of cancer in man. The journal publishes papers that warrant prompt publication in the areas of Biology, Genetics and Epigenetics (including the processes of promotion, progression, signal transduction, apoptosis, genomic instability, growth factors, cell and molecular biology, mutation, DNA repair, genetics, etc.), Cancer Biomarkers and Molecular Epidemiology (including genetic predisposition to cancer, and epidemiology), Inflammation, Microenvironment and Prevention (including molecular dosimetry, chemoprevention, nutrition and cancer, etc.), and Carcinogenesis (including oncogenes and tumor suppressor genes in carcinogenesis, therapy resistance of solid tumors, cancer mouse models, apoptosis and senescence, novel therapeutic targets and cancer drugs).
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