Molecular hybridization: a powerful tool for multitarget drug discovery.

IF 6 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Expert Opinion on Drug Discovery Pub Date : 2024-04-01 Epub Date: 2024-03-08 DOI:10.1080/17460441.2024.2322990
Pedro de Sena Murteira Pinheiro, Lucas Silva Franco, Tadeu Lima Montagnoli, Carlos Alberto Manssour Fraga
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引用次数: 0

Abstract

Introduction: The current drug discovery paradigm of 'one drug, multiple targets' has gained attention from both the academic medicinal chemistry community and the pharmaceutical industry. This is in response to the urgent need for effective agents to treat multifactorial chronic diseases. The molecular hybridization strategy is a useful tool that has been widely explored, particularly in the last two decades, for the design of multi-target drugs.

Areas covered: This review examines the current state of molecular hybridization in guiding the discovery of multitarget small molecules. The article discusses the design strategies and target selection for a multitarget polypharmacology approach to treat various diseases, including cancer, Alzheimer's disease, cardiac arrhythmia, endometriosis, and inflammatory diseases.

Expert opinion: Although the examples discussed highlight the importance of molecular hybridization for the discovery of multitarget bioactive compounds, it is notorious that the literature has focused on specific classes of targets. This may be due to a deep understanding of the pharmacophore features required for target binding, making targets such as histone deacetylases and cholinesterases frequent starting points. However, it is important to encourage the scientific community to explore diverse combinations of targets using the molecular hybridization strategy.

分子杂交:发现多靶点药物的有力工具。
导言:当前 "一药多靶点 "的药物研发模式受到了药物化学学术界和制药业的关注。这是为了满足治疗多因素慢性疾病对有效药物的迫切需求。分子杂交策略是一种有用的工具,特别是在过去二十年中,已被广泛用于多靶点药物的设计:这篇综述探讨了分子杂交在指导多靶点小分子药物发现方面的现状。文章讨论了多靶点多药理学方法的设计策略和靶点选择,以治疗各种疾病,包括癌症、阿尔茨海默病、心律失常、子宫内膜异位症和炎症性疾病:尽管所讨论的例子突出了分子杂交对发现多靶点生物活性化合物的重要性,但众所周知的是,文献的重点是特定类别的靶点。这可能是由于对靶点结合所需的药理特征有了深入了解,因此组蛋白去乙酰化酶和胆碱酯酶等靶点经常成为研究的起点。不过,重要的是要鼓励科学界利用分子杂交策略探索靶标的不同组合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.20
自引率
1.60%
发文量
78
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Drug Discovery (ISSN 1746-0441 [print], 1746-045X [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on novel technologies involved in the drug discovery process, leading to new leads and reduced attrition rates. Each article is structured to incorporate the author’s own expert opinion on the scope for future development. The Editors welcome: Reviews covering chemoinformatics; bioinformatics; assay development; novel screening technologies; in vitro/in vivo models; structure-based drug design; systems biology Drug Case Histories examining the steps involved in the preclinical and clinical development of a particular drug The audience consists of scientists and managers in the healthcare and pharmaceutical industry, academic pharmaceutical scientists and other closely related professionals looking to enhance the success of their drug candidates through optimisation at the preclinical level.
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