The amide group and its preparation methods by acid-amine coupling reactions: an overview

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Pure and Applied Chemistry Pub Date : 2024-03-06 DOI:10.1515/pac-2023-1104

Sandra Agudo-Álvarez, Sandra S. Díaz-Mínguez, Raúl Benito-Arenas

引用次数: 0

Abstract

The amide bond is one of the most important structural units in nature, as it is part of the backbone of peptides and natural proteins, as well as some essential amino acids, DNA, RNA, hormones, or vitamins found in the body. Furthermore, this bond is significant in the pharmaceutical industry due to its presence in the structure of numerous APIs contained in drugs. This paper reviews the most important methods collected in the bibliography for the preparation of this moiety.

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酰胺基团及其通过酸胺偶联反应制备的方法：综述

酰胺键是自然界中最重要的结构单元之一，因为它是肽和天然蛋白质，以及人体内某些必需氨基酸、DNA、RNA、激素或维生素的骨架的一部分。此外，由于这种键存在于药物中所含的大量原料药的结构中，因此在制药业中也具有重要意义。本文回顾了书目中收集的制备这种分子的最重要方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pure and Applied Chemistry 化学-化学综合

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Pure and Applied Chemistry is the official monthly Journal of IUPAC, with responsibility for publishing works arising from those international scientific events and projects that are sponsored and undertaken by the Union. The policy is to publish highly topical and credible works at the forefront of all aspects of pure and applied chemistry, and the attendant goal is to promote widespread acceptance of the Journal as an authoritative and indispensable holding in academic and institutional libraries.