EVALUATION OF THE RELATIOSHIP BETWEEN ADVANCED MATERNAL AGE AND PREGNANCY OUTCOME: A SCOPING REVIEW

medRxiv - Obstetrics and Gynecology Pub Date : 2024-03-07 DOI:10.1101/2024.03.05.24303764

Innocent Okafor Eze, Oliver Ezechi, Ahmadu Shehu Mohammed, Uchenna Ifeanyi Nwagha

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Abstract

Background Childbirth at advanced maternal age (AMA) is increasing among women, and some studies have shown adverse outcomes. There is a need to map evidence on the subject to harness findings and identify research gaps for further studies. This scoping review aims to examine pertinent studies on AMA and its impact on pregnancy outcomes. Methods The Preferred Reporting Item for Systematic Review and Meta-Analysis (PRISMA) chart is employed for systematic data extraction. This review draws from Google Scholar, the Cochrane Library, Medline (via PubMed), and Embase (via OVID). For inclusion in this scoping review, articles must thoroughly examine and elucidate the effects, impacts, and relationships between advanced maternal age and pregnancy outcomes. A crucial prerequisite is that the articles undergo a peer-review process to ensure the reliability and credibility of the presented information. For this review, advanced maternal age is defined explicitly as women aged ≥35. However, studies focusing on women aged ≥40 are also considered, mainly if they are high quality. In terms of research methodology, both primary and secondary research will be eligible, encompassing systematic reviews and meta-analyses. This broad inclusion aims to capture a comprehensive overview of the existing literature on the subject. Furthermore, articles must be presented in the English language to facilitate a standardized and accessible analysis. This criterion ensures that language barriers do not impede the review's ability to synthesize relevant information effectively. Results There are significant associations between advanced maternal age and poor pregnancy outcomes, even when adjusted for confounders. Conclusions The adverse pregnancy outcome due to maternal age alone may be due to placental dysfunction resulting from a relative deficiency in maternal cardiovascular adaptations to pregnancy, and this provides a window for further studies

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评估高龄产妇与妊娠结局之间的关系：范围审查

背景高龄产妇（AMA）越来越多，一些研究显示会产生不良后果。有必要对相关证据进行梳理，以利用研究结果并确定进一步研究的空白点。本范围综述旨在研究有关高龄产妇及其对妊娠结局影响的相关研究。方法采用系统性综述和荟萃分析首选报告项目（PRISMA）表进行系统性数据提取。本综述从 Google Scholar、Cochrane 图书馆、Medline（通过 PubMed）和 Embase（通过 OVID）中提取数据。要纳入本次范围界定综述，文章必须深入研究并阐明高龄产妇与妊娠结局之间的作用、影响和关系。一个重要的前提条件是这些文章必须经过同行评审，以确保所提供信息的可靠性和可信度。在本综述中，高龄产妇明确定义为年龄≥35 岁的女性。不过，以年龄≥40 岁的女性为重点的研究也在考虑之列，主要是质量较高的研究。在研究方法方面，初级研究和二级研究均符合条件，包括系统综述和荟萃分析。这种广泛的收录方式旨在对该主题的现有文献进行全面概述。此外，文章必须用英语撰写，以便于进行标准化的分析。结果即使对混杂因素进行调整，高龄产妇与不良妊娠结局之间仍存在显著关联。结论仅由高龄产妇引起的不良妊娠结局可能是由于产妇心血管对妊娠的适应性相对不足导致胎盘功能障碍所致，这为进一步研究提供了窗口。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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medRxiv - Obstetrics and Gynecology

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