[Plasmablastic lymphoma presenting with plasmacytosis and polyclonal hypergammopathy].

Keiichi Uraisami, Masuho Saburi, Katsuya Kawano, Yosuke Kodama, Hiroyuki Takata, Yasuhiko Miyazaki, Junpei Wada, Shogo Urabe, Eiichi Ohtsuka
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引用次数: 0

Abstract

A 72-year-old woman presented with generalized lymphadenopathies and plasmacytosis accompanied by polyclonal hypergammopathy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) showed FDG accumulation in the systemic lymph nodes, spleen, and multiple bones. Human immunodeficiency virus antibody was negative. Lymph node histologic findings showed a monotonous population of plasma cells with a starry-sky appearance. The cells were positive for CD19, λ, and Epstein-Barr virus-encoded RNA, and negative for CD20 and CD56. The MIB-1 index was 80%. A diagnosis of plasmablastic lymphoma with plasmacytosis and polyclonal hypergammopathy was made, and complete metabolic response was achieved after six cycles of dose-adjusted-EPOCH therapy (etoposide, prednisolone, vincristine, cyclophosphamide, and doxorubicin).

[浆细胞性淋巴瘤伴有浆细胞增多症和多克隆性高炎症]。
一名 72 岁的妇女出现全身淋巴结病和浆细胞增多症,并伴有多克隆性高炎症。18F-氟脱氧葡萄糖正电子发射断层扫描(FDG-PET)显示,全身淋巴结、脾脏和多处骨骼中均有FDG蓄积。人类免疫缺陷病毒抗体呈阴性。淋巴结组织学检查结果显示,浆细胞群单调,呈星空状。细胞的CD19、λ和Epstein-Barr病毒编码的RNA呈阳性,CD20和CD56呈阴性。MIB-1指数为80%。经过六个周期的剂量调整-EPOCH疗法(依托泊苷、泼尼松龙、长春新碱、环磷酰胺和多柔比星)后,患者获得了完全代谢反应。
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