PHASE ANGLE AS A PREDICTOR OF MUSCLE MASS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.

Q2 Medicine

Arquivos de Gastroenterologia Pub Date : 2024-03-04 eCollection Date: 2024-01-01 DOI:10.1590/S0004-2803.246102023-95

Angela Martinha Bongiolo, Marcos José Machado, Bruno Ayala Lazarotto, Maria Luiza Cimardi Rupp, Felipe Dal-Pizzol, Maria Marlene de Souza Pires

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引用次数: 0

Abstract

Background: Malnutrition/sarcopenia is frequent in patients with inflammatory bowel diseases (IBD), and results in muscle catabolism, impacting treatment response, postoperative complications, and quality of life.

Objective: This study aims to assess whether the phase angle (PhA) is a parameter for predicting reduced muscle mass in patients with IBD.

Methods: Adult patients with IBD were included in this cross-sectional study. For the estimation of muscle mass and the calculation of the PhA, we used bioelectrical impedance analysis (BIA). Crohn's disease (CD) and ulcerative colitis (UC) activity scores were defined using the Harvey-Bradshaw index and partial Mayo score, respectively. The area under the ROC curve was calculated to identify the PhA cut-off point for reduced muscle mass.

Results: The sample consisted of 145 patients, with 39 (26.9%) with IBD in the active phase. There was a correlation of the PhA with skeletal muscle mass (SMM) (rs 0.35, P<0.001) and with the skeletal muscle mass index (SMI) (rs 0.427, P<0.001), and the associations remained in the most active form (moderate or severe) of IBD. The ROC curve analysis indicated that the cut-offs points of the PhA ≤5.042 for female and PhA ≤6.079 for male can be used to predict muscle mass reduction.

Conclusion: The PhA can be considered a predictor of muscle mass reduction in IBD patients, and we can use it for screening and monitoring the evolution of malnutrition.

Background: • This study aims to assess whether the phase angle is a parameter for predicting reduced muscle mass in patients with inflammatory bowel disease.

Background: • There was a correlation of the phase angle with skeletal muscle mass and the associations remained in disease activity.

Background: • The ROC curve analysis indicated that the cut-off point of the PhA ≤5.042° for women and PhA ≤6,079° for men can be used to predict muscle mass reduction.

Background: • The phase angle can be considered a predictor of muscle mass reduction in inflammatory bowel disease.

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相位角作为炎症性肠病患者肌肉质量的预测指标。

背景：营养不良/肌肉疏松症在炎症性肠病（IBD）患者中很常见，会导致肌肉分解，影响治疗反应、术后并发症和生活质量：本研究旨在评估相位角（PhA）是否是预测 IBD 患者肌肉质量下降的一个参数：这项横断面研究纳入了成年 IBD 患者。为了估算肌肉质量和计算相位角，我们使用了生物电阻抗分析法（BIA）。克罗恩病（CD）和溃疡性结肠炎（UC）的活动度评分分别采用哈维-布拉德肖指数和部分梅奥评分来定义。通过计算 ROC 曲线下的面积来确定肌肉质量减少的 PhA 临界点：样本由 145 名患者组成，其中 39 人（26.9%）为活动期 IBD 患者。PhA与骨骼肌质量（SMM）存在相关性（rs 0.35，PC结论：PhA可被视为IBD患者肌肉量减少的预测指标，我们可以用它来筛查和监测营养不良的演变情况：- 本研究旨在评估相位角是否是预测炎症性肠病患者肌肉质量下降的参数：- 相位角与骨骼肌质量存在相关性，且在疾病活动时仍存在相关性：- ROC曲线分析表明，女性PHA≤5.042°和男性PHA≤6,079°的临界点可用于预测肌肉质量下降：- 背景：相位角可被视为炎症性肠病患者肌肉质量下降的预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de Gastroenterologia Medicine-Gastroenterology

CiteScore

2.00

自引率

0.00%

发文量

109

审稿时长

9 weeks

期刊介绍： The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.