Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study.

IF 9 1区 医学 Q1 RESPIRATORY SYSTEM
Thorax Pub Date : 2024-07-16 DOI:10.1136/thorax-2022-219666
Sarah Koch, Gabriela Prado Peralta, Anne-Elie Carsin, Alicia Abellan, Celine Roda, Maties Torrent, Carmen Iñiguez, Ferran Ballester, Amparo Ferrero, Carlos Zabaleta, Aitana Lertxundi, Mònica Guxens, Martine Vrijheid, Jordi Sunyer, Maribel Casas, Judith Garcia-Aymerich
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Abstract

Objective: The existence of catch-up lung function growth and its predictors is uncertain. We aimed to identify lung function trajectories and their predictors in a population-based birth cohort.

Methods: We applied group-based trajectory modelling to z-scores of forced expiratory volume in 1 second (zFEV1) and z-scores of forced vital capacity (zFVC) from 1151 children assessed at around 4, 7, 9, 10, 11, 14 and 18 years. Multinomial logistic regression models were used to test whether potential prenatal and postnatal predictors were associated with lung function trajectories.

Results: We identified four lung function trajectories: a low (19% and 19% of the sample for zFEV1 and zFVC, respectively), normal (62% and 63%), and high trajectory (16% and 13%) running in parallel, and a catch-up trajectory (2% and 5%) with catch-up occurring between 4 and 10 years. Fewer child allergic diseases and higher body mass index z-score (zBMI) at 4 years were associated with the high and normal compared with the low trajectories, both for zFEV1 and zFVC. Increased children's physical activity during early childhood and higher zBMI at 4 years were associated with the catch-up compared with the low zFEV1 trajectory (relative risk ratios: 1.59 per physical activity category (1.03-2.46) and 1.47 per zBMI (0.97-2.23), respectively). No predictors were identified for zFVC catch-up growth.

Conclusion: We found three parallel-running and one catch-up zFEV1 and zFVC trajectories, and identified physical activity and body mass at 4 years as predictors of zFEV1 but not zFVC catch-up growth.

体力活动和体重与儿童期肺功能追赶性增长的关系:一项基于人群的加速队列研究。
目的:是否存在肺功能追赶性增长及其预测因素尚不确定。我们旨在确定基于人群的出生队列中的肺功能轨迹及其预测因素:我们对 1151 名分别在 4、7、9、10、11、14 和 18 岁左右接受评估的儿童的 1 秒用力呼气容积 (zFEV1) z 值和用力肺活量 (zFVC) z 值进行了分组轨迹建模。我们使用多叉逻辑回归模型来检验潜在的产前和产后预测因素是否与肺功能轨迹相关:我们发现了四种肺功能轨迹:低轨迹(zFEV1和zFVC分别占样本的19%和19%)、正常轨迹(62%和63%)和高轨迹(16%和13%)并行,以及追赶轨迹(2%和5%),追赶发生在4至10岁之间。就 zFEV1 和 zFVC 而言,高轨迹和正常轨迹与低轨迹相比,儿童过敏性疾病较少,4 岁时体重指数 z 值(zBMI)较高。与低zFEV1轨迹相比,儿童早期体力活动的增加和4岁时较高的zBMI与追赶轨迹相关(相对风险比:1.59/体力活动类别(zBMI)):每个体力活动类别的相对风险比为 1.59(1.03-2.46),每个 zBMI 的相对风险比为 1.47(0.97-2.23))。没有发现zFVC追赶增长的预测因素:我们发现了三个并行和一个追赶的 zFEV1 和 zFVC 增长轨迹,并确定了 4 年时体力活动和体重是 zFEV1 增长的预测因素,但不是 zFVC 追赶增长的预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Thorax
Thorax 医学-呼吸系统
CiteScore
16.10
自引率
2.00%
发文量
197
审稿时长
1 months
期刊介绍: Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.
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