Correlation Between Blood Cadmium Levels and Platelet Characteristics, As Well As Their Impact on Susceptibility to Coronary Heart Disease: Findings from NHANES 2005-2018 Data.

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Toxicology Pub Date : 2024-04-01 Epub Date: 2024-03-06 DOI:10.1007/s12012-024-09840-x
Jichen Ci, Yuze Zhai, Benjun Wang, Weiwei Han, Bianfang Yu, Fan An
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引用次数: 0

Abstract

Investigating the correlation between blood cadmium levels, platelet characteristics, and susceptibility to coronary heart disease (CHD). Utilized NHANES 2005-2018 data with covariates such as age, sex, race, marital status, and socio-economic status. Blood cadmium served as the independent variable, while platelet count (PC) and mean platelet volume (MPV) were dependent variables. The average age of the participants was 68.77 ± 11.03 years, and 67.4% of them were male. The mean values for WBC, MPV, PC, and blood cadmium were 7.53 ± 3.36 × 103 cells/µL, 11.33 ± 0.27fL, 57.61 ± 5.34 × 103 cells/µL, and 2.58 ± 0.61 µg/L, respectively. Adjusting for other variables revealed increased MPV and PC with rising blood cadmium levels in cardiac patients, indicating a higher risk of CHD in those with elevated blood cadmium. The average age of the participants was 68.77 ± 11.03 years, and 67.4% of them were male. The mean values for WBC, MPV, PC, and blood cadmium were 7.53 ± 3.36 × 103 cells/µL, 11.33 ± 0.27fL, 57.61 ± 5.34 × 103 cells/µL, and 2.58 ± 0.61 µg/L, respectively. Adjusting for other variables revealed increased MPV and PC with rising blood cadmium levels in cardiac patients, indicating a higher risk of CHD in those with elevated blood cadmium. This study enhances understanding of how cadmium impacts platelet characteristics, contributing to increased CHD risk, providing insights for primary prevention strategies.

Abstract Image

血镉水平与血小板特征之间的相关性及其对冠心病易感性的影响:来自 NHANES 2005-2018 年数据的研究结果。
调查血镉水平、血小板特征与冠心病(CHD)易感性之间的相关性。利用 NHANES 2005-2018 年的数据以及年龄、性别、种族、婚姻状况和社会经济状况等协变量。血镉是自变量,血小板计数(PC)和平均血小板体积(MPV)是因变量。参与者的平均年龄为(68.77 ± 11.03)岁,67.4%为男性。WBC、MPV、PC 和血镉的平均值分别为 7.53 ± 3.36 × 103 cells/µL、11.33 ± 0.27fL、57.61 ± 5.34 × 103 cells/µL 和 2.58 ± 0.61 µg/L。对其他变量进行调整后发现,心脏病患者的 MPV 和 PC 会随着血镉水平的升高而增加,这表明血镉升高的患者罹患心脏病的风险更高。参与者的平均年龄为(68.77 ± 11.03)岁,67.4%为男性。WBC、MPV、PC和血镉的平均值分别为7.53 ± 3.36 × 103 cells/μL、11.33 ± 0.27fL、57.61 ± 5.34 × 103 cells/μL和2.58 ± 0.61 µg/L。对其他变量进行调整后发现,心脏病患者的 MPV 和 PC 会随着血镉水平的升高而增加,这表明血镉升高的患者罹患心脏病的风险更高。这项研究加深了人们对镉如何影响血小板特性、导致冠心病风险增加的认识,为一级预防策略提供了启示。
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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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