Fluconazole Microsponges Loaded Bioadhesive Vaginal Film to Treat Vulvovaginal Candidiasiss

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Innovation Pub Date : 2024-03-05 DOI:10.1007/s12247-024-09822-0

Priti L. Mandlik, Palakshi R. Lad, Ashlesha P. Pandit

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引用次数: 0

Abstract

Purpose

The purpose of this study was to develop fluconazole microsponges loaded bioadhesive film, rolled into a torpedo-shaped capsule, to achieve ease of application and reduce application frequency for the treatment of vulvovaginal candidiasis. This was accomplished by using biodegradable polymer blend specifically designed to cater the busy lifestyle of working women.

Methods

Microsponges were prepared using the quasi-emulsion solvent diffusion method. Herein, fluconazole: ethyl cellulose (1:2.5, 1:3, 1:3.5) and polyvinyl alcohol (used as the external phase) were dissolved in dichloromethane (12.5, 15, 17.5 ml). Three-level, two-factor full-factorial design optimized the above process. Next, the developed microsponges were thoroughly evaluated for entrapment efficiency, drug release and antimicrobial study. Lastly, film was developed which was made up of blend of bioadhesive polymers, namely pectin and xanthan gum. Subsequently, film was rolled into a torpedo-shaped capsule shell.

Results

The spherical-shaped porous microsponges exhibited a notable entrapment efficiency (94.17%), size 14.68 μm and rapid drug release of 91.1 ± 1.54% within 10 h. Further, bioadhesive film revealed thickness 92 μm, folding endurance 440, moisture content 5.66 ± 0.51% w/w, and good tensile strength to withstand vaginal pressure and remarkable zone of inhibition against Candida albicans (19.1 mm).

Conclusion

Fluconazole microsponges loaded bioadhesive film, rolled into a torpedo-shaped capsule, exhibited an excellent aesthetic appearance. Moreover, strong bioadhesivity ensured a high efficacy in combating disease.

Abstract Image

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装载氟康唑微海绵的生物黏附性阴道膜治疗外阴阴道念珠菌病

目的本研究的目的是开发装载氟康唑的微海绵生物粘合膜，将其卷成鱼雷形胶囊，以方便使用并减少使用频率，用于治疗外阴阴道念珠菌病。方法采用准乳液溶剂扩散法制备微型海绵。将氟康唑：乙基纤维素（1:2.5、1:3、1:3.5）和聚乙烯醇（用作外相）溶于二氯甲烷（12.5、15、17.5 毫升）。三级双因素全因子设计优化了上述过程。接着，对开发的微海绵进行了全面的夹持效率、药物释放和抗菌研究评估。最后，开发了由生物粘附性聚合物（即果胶和黄原胶）混合而成的薄膜。结果球形多孔微海绵显示出显著的夹持效率（94.17%），尺寸为 14.68 μm，在 10 小时内药物快速释放率为 91.1 ± 1.54%。结论含有氟康唑的微海绵生物粘合薄膜卷成鱼雷形胶囊后，外观非常美观。此外，强大的生物粘附性确保了其在抗病方面的高效性。

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.