Comparative Effectiveness of Bimekizumab and Secukinumab in Patients with Psoriatic Arthritis at 52 Weeks Using a Matching-Adjusted Indirect Comparison.
IF 2.9
3区 医学
Q2 RHEUMATOLOGY
引用次数: 0
Abstract
Introduction: Matching-adjusted indirect comparisons (MAICs) were used to compare the efficacy of bimekizumab and secukinumab 150 mg and 300 mg at 52 weeks for the treatment of psoriatic arthritis (PsA) in patients who were biologic disease-modifying anti-rheumatic drug-naïve (bDMARD-naïve) or with previous inadequate response or intolerance to tumor necrosis factor inhibitors (TNFi-IR).
Methods: Relevant trials were systematically identified. Individual patient data from bimekizumab randomized controlled trials, BE OPTIMAL (N = 431) and BE COMPLETE (N = 267), were matched to aggregate data from bDMARD-naïve and TNFi-IR patient subgroups from FUTURE 2 using secukinumab 150 mg and 300 mg doses (bDMARD-naïve: N = 63/37; TNFi-IR: N = 67/33). To adjust for cross-trial differences, patients from the bimekizumab trials were re-weighted using propensity scores to match the baseline characteristics of patients in the secukinumab trials. Unanchored comparisons of recalculated bimekizumab and secukinumab 52-week non-responder imputation outcomes for 20/50/70% improvement in American College of Rheumatology score (ACR20/50/70) and minimal disease activity (MDA) index were analyzed.
Results: In patients who were bDMARD-naïve, bimekizumab had a greater likelihood of ACR70 response than secukinumab 150 mg (odds ratio [95% confidence interval] 2.39 [1.26, 4.53]; p = 0.008) and secukinumab 300 mg (2.03 [1.11, 3.72]; p = 0.021) at 52 weeks. In patients who were TNFi-IR, bimekizumab had a greater likelihood of response compared to secukinumab 150 mg for ACR20 (3.50 [1.64-7.49]; p = 0.001), ACR50 (3.32 [1.41, 7.80]; p = 0.006), ACR70 (2.95 [1.08, 8.07]; p = 0.035) and MDA (3.52 [1.38, 8.99]; p = 0.009), and a greater likelihood of response compared to secukinumab 300 mg for ACR50 (2.44 [1.06, 5.65]; p = 0.037) and MDA (2.92 [1.20, 7.09]; p = 0.018) at 52 weeks.
Conclusion: In this MAIC analysis, the efficacy of bimekizumab, as demonstrated by the likelihood of ACR20/50/70 and MDA response at 52 weeks, was greater or comparable to secukinumab 150 mg and 300 mg for patients with PsA who were bDMARD-naïve and TNFi-IR.
Trial registration numbers: NCT03895203, NCT03896581, NCT04009499, NCT01752634, NCT01989468, NCT02294227, NCT02404350.
使用匹配调整间接比较法比较 Bimekizumab 和 Secukinumab 对银屑病关节炎患者 52 周的疗效。
简介：采用匹配调整间接比较法（MAICs）比较bimekizumab和secukinumab 150毫克和300毫克治疗银屑病关节炎（PsA）52周的疗效：系统地确定了相关试验。将来自bimekizumab随机对照试验BE OPTIMAL（N = 431）和BE COMPLETE（N = 267）的单个患者数据与来自FUTURE 2使用secukinumab 150 mg和300 mg剂量的bDMARD-naïve和TNFi-IR患者亚组的总数据进行匹配（bDMARD-naïve：N = 63/37；TNFi-IR：N = 67/33）。为了调整跨试验差异，使用倾向评分对来自bimekizumab试验的患者进行了重新加权，以匹配secukinumab试验中患者的基线特征。对重新计算的bimekizumab和secukinumab 52周非应答者的美国风湿病学会评分（ACR20/50/70）改善20%/50%/70%和最小疾病活动度（MDA）指数的非锚定比较结果进行了分析：在bDMARD无效的患者中，52周时bimekizumab比secukinumab 150 mg（几率比[95%置信区间]2.39 [1.26，4.53]；p = 0.008）和secukinumab 300 mg（2.03 [1.11，3.72]；p = 0.021）获得ACR70应答的可能性更大。在 TNFi-IR 患者中，与 secukinumab 150 mg 相比，bimekizumab 在 ACR20（3.50 [1.64-7.49]; p = 0.001）、ACR50（3.32 [1.41-7.80]; p = 0.006）、ACR70（2.95 [1.08-8.07]; p = 0.035) 和 MDA (3.52 [1.38, 8.99]; p = 0.009)，与 secukinumab 300 mg 相比，52 周时 ACR50 (2.44 [1.06, 5.65]; p = 0.037) 和 MDA (2.92 [1.20, 7.09]; p = 0.018)的应答可能性更大：在这项MAIC分析中，对于bDMARD无效且TNFi-IR的PsA患者，52周时ACR20/50/70和MDA应答的可能性表明，bimekizumab的疗效高于或相当于secukinumab 150 mg和300 mg：试验注册号：NCT03895203、NCT03896581、NCT04009499、NCT01752634、NCT01989468、NCT02294227、NCT02404350。
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来源期刊
Rheumatology and Therapy
RHEUMATOLOGY-
CiteScore
6.00
自引率
5.30%
发文量
91
审稿时长
6 weeks
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