Impact of Immune Cells on Stroke Limited to Specific Subtypes: Evidence from Mendelian Randomization Study.

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Neurology and Therapy Pub Date : 2024-06-01 Epub Date: 2024-03-06 DOI:10.1007/s40120-024-00592-y

Chen Chen, Qi Liu, Yao Li, Jingwen Yu, Shudi Wang, Li Liu

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引用次数: 0

Abstract

Introduction: Stroke is one of the common diseases that pose a severe threat to human health, with immune cells playing a crucial role in its onset and recovery. However, the specific mechanisms and causal relationships of different immune cell groups in various clinical stroke subtypes are unclear. This study explored the causal relationship between immune cells and stroke and its subtypes using Mendelian randomization (MR) analysis.

Methods: Data from genome-wide association studies were analyzed using inverse-variance weighted (IVW), MR-Egger, and weighted median methods for MR analysis, along with heterogeneity tests, sensitivity analysis, and pleiotropy analysis.

Results: CD45RA⁺CD28^-CD8⁺ T cell %T cell (OR 1.002, 95% CI 1.001-1.003; P_FDR = 0.02), CD27 on CD24⁺CD27⁺ B cell (OR 1.127, 95% CI 1.061-1.198; P_FDR = 0.04), CD27 on IgD^-CD38^dim B cell (OR 1.138, 95% CI 1.076-1.203; P_FDR = 0.005), and CD27 on switched memory B cell (OR 1.144, 95% CI 1.076-1.216; P_FDR = 0.01) were found to increase the risk of large artery stroke. Switched memory B cell %lymphocyte (OR 1.206, 95% CI 1.103-1.318; P_FDR = 0.02) increased the risk of small vessel stroke. Reverse MR analysis did not reveal any reverse causal associations. Furthermore, by substituting the outcome data, a secondary MR analysis was conducted to validate the primary findings.

Conclusion: Our study reveals several causal links between immune phenotypes and stroke and its different subtypes, highlighting the complex interactions between the immune system and stroke. These findings provide new directions for further uncovering the biological basis of stroke and assist in advancing research on early interventions and treatment strategies.

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免疫细胞对特定亚型中风的影响：孟德尔随机研究的证据

简介脑卒中是严重威胁人类健康的常见疾病之一，免疫细胞在脑卒中的发病和恢复过程中起着至关重要的作用。然而，不同免疫细胞群在各种临床中风亚型中的具体机制和因果关系尚不清楚。本研究采用孟德尔随机分析法（MR）探讨了免疫细胞与中风及其亚型之间的因果关系：采用反方差加权法（IVW）、MR-Egger法和加权中位数法进行MR分析，并进行异质性检验、敏感性分析和多向性分析：CD45RA+CD28-CD8+T细胞%T细胞（OR 1.002，95% CI 1.001-1.003；PFDR = 0.02）、CD24+CD27+B细胞上的CD27（OR 1.127，95% CI 1.061-1.198；PFDR = 0.04）、IgD-CD38dim B细胞上的CD27（OR 1.138，95% CI 1.076-1.203；PFDR = 0.005）和切换记忆B细胞上的CD27（OR 1.144，95% CI 1.076-1.216；PFDR = 0.01）被发现会增加大动脉卒中的风险。切换记忆 B 细胞淋巴细胞百分比（OR 1.206，95% CI 1.103-1.318；PFDR = 0.02）增加了小血管卒中的风险。反向 MR 分析未发现任何反向因果关系。此外，通过替换结果数据，进行了二次磁共振分析，以验证主要研究结果：我们的研究揭示了免疫表型与中风及其不同亚型之间的几种因果关系，突出了免疫系统与中风之间复杂的相互作用。这些发现为进一步揭示中风的生物学基础提供了新的方向，有助于推进早期干预和治疗策略的研究。

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来源期刊

Neurology and Therapy CLINICAL NEUROLOGY-

CiteScore

5.40

自引率

8.10%

发文量

103

审稿时长

6 weeks

期刊介绍： Aims and Scope Neurology and Therapy aims to provide reliable and inclusive, rapid publication for all therapy related research for neurological indications, supporting the timely dissemination of research with a global reach, to help advance scientific discovery and support clinical practice. Neurology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of neurological and psychiatric therapies, (also covering surgery and devices). Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial designs, communications and letters. 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