The role of baseline 2-[18F]-FDG-PET/CT metrics and radiomics features in predicting primary gastric lymphoma diagnosis

IF 3.3 4区 医学 Q2 HEMATOLOGY
Domenico Albano, Anna Calabrò, Francesco Dondi, Samuele Bagnasco, Alessandra Tucci, Francesco Bertagna
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引用次数: 0

Abstract

Diffuse Large B-Cell Lymphomas (DLCBL) and mucosa-associated lymphoid tissue (MALT) are the two most common primary gastric lymphomas (PGLs), but have strongly different features. DLBCL is more aggressive, is frequently diagnosed at an advanced stage and has a poorer prognosis. The aim of this retrospective study was to explore the role of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (2-[18F]-FDG-PET/CT) and radiomics features (RFs) in predicting the final diagnosis of patients with PGLs. Ninety-one patients with newly diagnosed PGLs who underwent pre-treatment 2-[18F]-FDG-PET/CT were included. PET images were qualitatively and semi-quantitatively analyzed by deriving maximum standardized uptake value body weight (SUVbw), maximum standardized uptake value lean body mass (SUVlbm), maximum standardized uptake value body surface area (SUVbsa), lesion to liver SUVmax ratio (L-L SUV R), lesion to blood-pool SUVmax ratio (L-BP SUV R), metabolic tumor volume (gMTV) and total lesion glycolysis of gastric lesion (gTLG), total MTV (tMTV), TLG, and first-order RFs (histogram-related and shape related). Receiver-operating characteristic (ROC) curve analyses were performed to determine the differential diagnostic values of PET parameters. The final diagnosis was DLBCL in 54 (59%) cases and MALT in 37 cases (41%). PGLs showed FDG avidity in 83 cases (90%), 54/54 of DLBCL and 29/37 of MALT. All PET/CT metabolic features, such as stage of disease and tumor size, were significantly higher in DLBCL than MALT; while the presence of H. Pylori infection was more common in MALT. At univariate analysis, all PET/CT metrics were significantly higher in DLBCL than MALT lymphomas, while among RFs only Shape volume_vx and Shape sphericity showed a significant difference between the two groups. In conclusion we demonstrated that 2-[18F]-FDG-PET/CT parameters can potentially discriminate between DLBCL and MALT lymphomas with high accuracy. Among first-order RFs, only Shape volume_vx and Shape sphericity helped in the differential diagnosis.

基线 2-[18 F]-FDG-PET/CT 指标和放射组学特征在预测原发性胃淋巴瘤诊断中的作用。
弥漫大B细胞淋巴瘤(DLBCL)和粘膜相关淋巴组织淋巴瘤(MALT)是两种最常见的原发性胃淋巴瘤(PGL),但它们的特征却截然不同。DLBCL更具侵袭性,常在晚期确诊,预后较差。这项回顾性研究旨在探讨氟-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(2-[18 F]-FDG-PET/CT)和放射组学特征(RFs)在预测PGL患者最终诊断中的作用。91名新确诊的PGL患者在治疗前接受了2-[18 F]-FDG-PET/CT检查。通过得出最大标准化摄取值体重(SUVbw)、最大标准化摄取值瘦体重(SUVlbm)、最大标准化摄取值体表面积(SUVbsa),对 PET 图像进行定性和半定量分析、病变与肝脏的 SUVmax 比值(L-L SUV R)、病变与血池的 SUVmax 比值(L-BP SUV R)、代谢肿瘤体积(gMTV)和胃病变的总病变糖酵解量(gTLG)、总 MTV(tMTV)、TLG 和一阶 RF(直方图相关和形状相关)。为确定 PET 参数的鉴别诊断价值,进行了接收方操作特征(ROC)曲线分析。54例(59%)最终诊断为DLBCL,37例(41%)最终诊断为MALT。83例(90%)PGL显示FDG阳性,其中54/54例为DLBCL,29/37例为MALT。所有 PET/CT 代谢特征,如疾病分期和肿瘤大小,在 DLBCL 中均明显高于 MALT;而幽门螺杆菌感染在 MALT 中更为常见。单变量分析显示,DLBCL淋巴瘤的所有PET/CT指标均明显高于MALT淋巴瘤,而在RFs中,只有Shape volume_vx和Shape sphericity显示两组间存在显著差异。总之,我们证明了 2-[18 F]-FDG-PET/CT 参数能准确区分 DLBCL 和 MALT 淋巴瘤。在一阶射频参数中,只有Shape volume_vx和Shape sphericity有助于鉴别诊断。
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来源期刊
Hematological Oncology
Hematological Oncology 医学-血液学
CiteScore
4.20
自引率
6.10%
发文量
147
审稿时长
>12 weeks
期刊介绍: Hematological Oncology considers for publication articles dealing with experimental and clinical aspects of neoplastic diseases of the hemopoietic and lymphoid systems and relevant related matters. Translational studies applying basic science to clinical issues are particularly welcomed. Manuscripts dealing with the following areas are encouraged: -Clinical practice and management of hematological neoplasia, including: acute and chronic leukemias, malignant lymphomas, myeloproliferative disorders -Diagnostic investigations, including imaging and laboratory assays -Epidemiology, pathology and pathobiology of hematological neoplasia of hematological diseases -Therapeutic issues including Phase 1, 2 or 3 trials as well as allogeneic and autologous stem cell transplantation studies -Aspects of the cell biology, molecular biology, molecular genetics and cytogenetics of normal or diseased hematopoeisis and lymphopoiesis, including stem cells and cytokines and other regulatory systems. Concise, topical review material is welcomed, especially if it makes new concepts and ideas accessible to a wider community. Proposals for review material may be discussed with the Editor-in-Chief. Collections of case material and case reports will be considered only if they have broader scientific or clinical relevance.
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