[Research advances of prostaglandin E2 receptor 1 (EP1)].

Q3 Medicine
生理学报 Pub Date : 2024-02-25
Shu-Tao Chen, Shuang Ji, Mei-Na Guo, Li-Hong Chen
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引用次数: 0

Abstract

Prostaglandin E2 (PGE2) is an important lipid molecule derived from arachidonic acid, which regulates a variety of physiological and pathological activities. Based on the inhibition of inflammatory PGE2 production, non-steroidal anti-inflammatory drugs (NSAIDs) are considered as the most commonly used drugs to treat inflammatory diseases and to relieve fever and pain symptoms. PGE2 mediates its functions via four different G protein-coupled receptors, named EP1-EP4. Though the limited distribution and low PGE2 affinity of EP1, it plays important roles in the maintenance of many physiological functions and homeostasis. Moreover, EP1 is widely involved in the inflammatory response, pain perception and multisystem pathological function regulation. In this review, we will briefly summarize the recent advances on the physiological and pathophysiological function of EP1 and its targeted drugs development.

[前列腺素 E2 受体 1(EP1)的研究进展]。
前列腺素 E2(PGE2)是一种重要的脂质分子,来源于花生四烯酸,可调节多种生理和病理活动。非甾体抗炎药(NSAIDs)通过抑制炎症性 PGE2 的产生,被认为是治疗炎症性疾病、缓解发热和疼痛症状的最常用药物。PGE2 通过四种不同的 G 蛋白偶联受体(EP1-EP4)介导其功能。虽然 EP1 的分布范围有限且 PGE2 亲和力较低,但它在维持许多生理功能和平衡方面发挥着重要作用。此外,EP1 还广泛参与炎症反应、痛觉和多系统病理功能调节。在这篇综述中,我们将简要总结 EP1 生理和病理生理功能及其靶向药物开发的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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