[Abnormalities in signal transduction of Purkinje cells in spinocerebellar ataxias: a review].

Q3 Medicine
生理学报 Pub Date : 2024-02-25
Qiong Wu, Qing-Yun Huang, Guo-He Tan
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引用次数: 0

Abstract

Spinocerebellar ataxias (SCAs) are a group of autosomal dominant neurodegenerative diseases that have been currently identified with numerous subtypes exhibiting genetic heterogeneity and clinical variability. Purkinje neuronal degeneration and cerebellar atrophy are common pathological features among most SCA subtypes. The physiological functions of Purkinje cells are regulated by multiple factors, and their dysfunction in signal transduction may lead to abnormal cerebellar motor control. This review summarizes the abnormalities in voltage-gated ionic channels, intracellular calcium signaling, and glutamate signaling transduction of Purkinje cells in SCAs, aiming to provide a theoretical basis for further understanding the common pathogenesis of SCAs and developing specific treatments.

[脊髓小脑共济失调症中普金杰细胞信号传导异常:综述]。
脊髓小脑性共济失调症(SCA)是一组常染色体显性神经退行性疾病,目前已发现许多亚型,具有遗传异质性和临床变异性。普肯野神经元变性和小脑萎缩是大多数 SCA 亚型的共同病理特征。浦肯野细胞的生理功能受多种因素调控,其信号转导功能障碍可能导致小脑运动控制异常。本综述总结了SCA中普肯耶细胞的电压门控离子通道、细胞内钙信号转导和谷氨酸信号转导的异常,旨在为进一步了解SCA的共同发病机制和开发特异性治疗方法提供理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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