Comprehensive exercise reduces traumatic brain injury deficits via improving the neural network function of hippocampal CA1 and medial entorhinal cortex.

Q3 Medicine
生理学报 Pub Date : 2024-02-25
Yong-Zhi Li, Yu Wu, Meng-Qi Ma, Ji-Hui Wang, Xue-Fen Dong, Wei Ouyang
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引用次数: 0

Abstract

The present study aimed to investigate the alterations in functional interaction between hippocampal CA1 and medial entorhinal cortex (MEC) after moderate traumatic brain injury (TBI) in C57BL/6J mice, and the possible beneficial effects of comprehensive exercise (CE). Following TBI, two microelectrodes were implanted into CA1 and MEC for extracellular recording. We found a clear synchronization of neuronal firing in CA1 and MEC, particularly within 100 Hz and peaked at 20-30 Hz range. TBI induced a significant reduction (P < 0.001) of the coherences of firing between 20-40 Hz frequency band. The mean power spectral densities (PSD) of all group mice in MEC were steadily larger than the values in CA1 in both 20-40 Hz and 56-100 Hz ranges. TBI induced significant and consistent increases of averaged 20-40 Hz or 56-100 Hz PSD (P < 0.001 or P < 0.01) in both CA1 and MEC. Injured mice displayed more varied firing patterns, and showed increased burst frequency (BF), burst duration (BD), inter-spike intervals (ISI) and inter-burst interval (IBI). Injured mice also showed worsened neurological function, sleep, gait performance, and working memory. CE facilitated the restoration of aforementioned electrophysiological characteristics and functional deficits in TBI mice. These results suggest that the beneficial effects of CE on TBI functional deficits may be partly attributed to improved neuronal network interaction between CA1 and MEC.

通过改善海马CA1和内侧内耳皮层的神经网络功能,综合运动可减轻创伤性脑损伤的缺陷。
本研究旨在探讨C57BL/6J小鼠中度创伤性脑损伤(TBI)后海马CA1和内侧内视网膜皮层(MEC)之间功能相互作用的改变,以及综合运动(CE)可能产生的有益影响。TBI 后,在 CA1 和 MEC 植入两个微电极进行细胞外记录。我们发现,CA1和MEC的神经元发射有明显的同步性,尤其是在100赫兹范围内,在20-30赫兹范围内达到峰值。创伤性脑损伤导致20-40赫兹频段的神经元发射一致性明显降低(P < 0.001)。在20-40赫兹和56-100赫兹范围内,所有组小鼠MEC的平均功率谱密度(PSD)均持续大于CA1的值。创伤性脑损伤导致CA1和MEC中20-40 Hz或56-100 Hz的平均PSD持续显著增加(P < 0.001或P < 0.01)。受伤的小鼠表现出更多样的发射模式,并显示出突发性频率(BF)、突发性持续时间(BD)、尖峰间期(ISI)和突发性间期(IBI)的增加。受伤小鼠的神经功能、睡眠、步态表现和工作记忆也有所恶化。CE 有助于恢复创伤性脑损伤小鼠的上述电生理特征和功能障碍。这些结果表明,CE 对 TBI 功能障碍的有益影响可能部分归因于 CA1 和 MEC 之间神经元网络相互作用的改善。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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