Atorvastatin-induced Lupus Erythematosus Tumidus: A Case Report and Literature Review.

Katarina Trčko, Nuša Lukinovič, Boštjan Luzar
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Abstract

Lupus erythematosus tumidus (LET) is a rare photosensitive skin disease classified as a separate subtype of cutaneous lupus erythematosus. Clinically, it is characterized by erythematous plaques on sun-exposed areas. Typical histopathological findings are perivascular and periadnexal lymphohistiocytic infiltrates and prominent mucin deposition in the dermis. Treatment is based on photoprotection, topical corticosteroids, and antimalarial drugs. The exact pathogenesis of the disease is unknown. Drugs are considered a minor risk factor for the development of LET. We present a case of a 56-year-old woman who developed LET after starting treatment with atorvastatin. We describe her clinical course and review the literature concerning the cutaneous adverse reactions induced by statin drugs. To our knowledge, this is the first case of statin-induced LET. We conclude that statins can induce LET and that it is important for clinicians to be aware of this potential adverse effect associated with statins.

阿托伐他汀诱发的红斑狼疮瘤:病例报告与文献综述
肿瘤性红斑狼疮(LET)是一种罕见的光敏性皮肤病,被归类为皮肤红斑狼疮的一个独立亚型。在临床上,它的特征是在暴露于阳光的部位出现红斑。典型的组织病理学结果是血管周围和附件周围淋巴组织细胞浸润,真皮层有明显的粘蛋白沉积。治疗以光照保护、局部皮质类固醇激素和抗疟疾药物为主。该病的确切发病机制尚不清楚。药物被认为是诱发 LET 的次要危险因素。我们介绍了一例 56 岁女性的病例,她在开始使用阿托伐他汀治疗后出现了 LET。我们描述了她的临床病程,并回顾了有关他汀类药物诱发皮肤不良反应的文献。据我们所知,这是第一例他汀类药物诱发的 LET。我们的结论是他汀类药物可诱发 LET,临床医生必须意识到他汀类药物的这种潜在不良反应。
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