Causal link between gut microbiome and schizophrenia: a Mendelian randomization study.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2024-04-01 Epub Date: 2024-02-19 DOI:10.1097/YPG.0000000000000361

Qi Zeng, Min Zhang, Renxi Wang

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引用次数: 0

Abstract

Objective: Some observational studies have shown that gut microbiome is significantly changed in patients with schizophrenia. We aim to identify the genetic causal link between gut microbiome and schizophrenia.

Methods: A two-sample Mendelian randomization (MR) study was used to evaluate the causal link between gut microbiome and schizophrenia with 28 gut microbiome-associated genetic instrumental variants chosen from recent MR reports and the largest schizophrenia genome-wide association studies (8-Apr-22 release).

Results: Inverse variance weighted method showed that genetically increased Bacteroidales_S24-7 (per SD) resulted in increased risk of schizophrenia (OR = 1.110, 95% CI: [1.012-1.217], P = 0.027). Similarly, genetically increased Prevotellaceae promoted schizophrenia risk (OR = 1.124, 95% CI: [1.030-1.228], P = 0.009). However, genetically increased Lachnospiraceae reduced schizophrenia risk (OR = 0.878, 95% CI: [0.785-0.983], P = 0.023). In addition, schizophrenia risk was also suppressed by genetically increased Lactobacillaceae (OR = 0.878, 95% CI: [0.776-0.994], P = 0.040) and Verrucomicrobiaceae (OR = 0.860, 95% CI: [0.749-0.987], P = 0.032). Finally, we did not find any significant results in the causal association of other 23 gut microbiome with schizophrenia.

Conclusion: Our analysis suggests that genetically increased Bacteroidales_S24-7 and Prevotellaceae promotes schizophrenia risk, whereas genetically increased Lachnospiraceae, Lactobacillaceae, and Verrucomicrobiaceae reduces schizophrenia risk. Thus, regulation of the disturbed intestinal microbiota may represent a new therapeutic strategy for patients with schizophrenia.

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肠道微生物组与精神分裂症之间的因果关系：孟德尔随机研究。

目的：一些观察性研究表明，精神分裂症患者的肠道微生物组发生了显著变化。我们旨在确定肠道微生物组与精神分裂症之间的遗传因果关系：方法：采用双样本孟德尔随机化（Mendelian randomization，MR）研究，从最近的MR报告和最大的精神分裂症全基因组关联研究（8-Apr-22发布）中选取28个与肠道微生物相关的遗传工具变异，评估肠道微生物组与精神分裂症之间的因果关系：结果：逆方差加权法显示，类杆菌_S24-7（每标准差）的遗传增加导致精神分裂症风险增加（OR = 1.110，95% CI：[1.012-1.217]，P = 0.027）。同样，普雷沃特科（Prevotellaceae）基因的增加也会增加患精神分裂症的风险（OR = 1.124，95% CI：[1.030-1.228]，P = 0.009）。然而，遗传性增加的漆树科（Lachnospiraceae）会降低精神分裂症风险（OR = 0.878，95% CI：[0.785-0.983]，P = 0.023）。此外，乳酸菌属（OR = 0.878，95% CI：[0.776-0.994]，P = 0.040）和毛霉菌属（OR = 0.860，95% CI：[0.749-0.987]，P = 0.032）基因增殖也会抑制精神分裂症风险。最后，我们没有发现其他 23 种肠道微生物群与精神分裂症的因果关系：我们的分析表明，类杆菌科（Bacteroidales_S24-7）和前鞭毛菌科（Prevotellaceae）的遗传增加会增加精神分裂症的风险，而Lachnospiraceae、Lactobacillaceae和Verrucomicrobiaceae的遗传增加则会降低精神分裂症的风险。因此，调节紊乱的肠道微生物群可能是精神分裂症患者的一种新的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.