Factors in the Neonatal Period Associated With Pulmonary Hypertension at 28 Days of Life in Broncho-Pulmonary Dysplasia.

IF 1.4 Q3 PEDIATRICS

Global Pediatric Health Pub Date : 2024-03-03 eCollection Date: 2024-01-01 DOI:10.1177/2333794X241234571

Nguyen Thi Hai Anh, Tran Minh Dien, Le Thi Ha, Pham Thao Nguyen, Dang Thi Hai Van

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Abstract

Objectives. To identify factors associated with pulmonary hypertension (PH) at 28 days of life in preterm infants with bronchopulmonary dysplasia (BPD). Methods. This observational study included 128 premature infants with BPD between January 2022 and February 2023 from the neonatal intensive care unit of Vietnam National Children's Hospital. Results. PH was observed using echocardiography in 29 patients (22.66%). The prevalence of severe BPD in the PH group (62.07%) was significantly higher than that in the non-PH group (18.18%). The multivariate logistic regression showed 2 predictors of PH in BPD: invasive mechanical ventilation up to 28 days of life (odds ratio [OR]:9.440; 95% confidence interval [CI]: 3.090-28.833; P < .001) and history of shock (OR: 2.962; 95% CI: 1.067-8.225; P = .037). Conclusion. We found 2 predictors of PH at 28 days of life in BPD: invasive mechanical ventilation up to 28 days of life and history of shock.

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与支气管肺发育不良患者出生 28 天后肺动脉高压有关的新生儿期因素

研究目的确定与患有支气管肺发育不良（BPD）的早产儿出生 28 天时肺动脉高压（PH）相关的因素。方法。这项观察性研究纳入了2022年1月至2023年2月期间越南国家儿童医院新生儿重症监护室的128名BPD早产儿。结果29 名患者（22.66%）通过超声心动图观察到 PH。PH组（62.07%）严重BPD的发生率明显高于非PH组（18.18%）。多变量逻辑回归显示，有两个因素可预测 BPD 患者的 PH：出生后 28 天内的侵入性机械通气（几率比 [OR]：9.440；95% 置信区间 [CI]：3.090-28.833）：3.090-28.833; p p = .037）。结论我们发现有两个因素可预测 BPD 患者出生 28 天后的 PH：出生 28 天前的侵入性机械通气和休克史。

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