Can our experience with surveillance for inherited pancreatic cancer help to identify early pancreatic cancer in the general population?

IF 1.8 4区医学 Q3 GENETICS & HEREDITY

Familial Cancer Pub Date : 2024-08-01 Epub Date: 2024-03-05 DOI:10.1007/s10689-024-00363-6

J-Matthias Löhr, Daniel Öhlund, Emma Söreskog, Emil Andersson, Miroslav Vujasinovic, Niklas Zethraeus, Malin Sund

引用次数: 0

Abstract

Screening of the general population for cancer is a matter of primary prevention reducing the burden of disease. Whilst this is successful for several cancers including breast, colon and prostate, the situation to screen and hence prevent pancreatic cancer is different. The organ is not as accessible to simple physical exam or biological samples (fecal or blood test). Neither exists a blood test such as PSA that is cost-effective. Reviewing the evidence from screening risk groups for pancreatic cancer, one must conclude that there is no rational at present to screen the general population, for a lack of appropriate tests.

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我们监测遗传性胰腺癌的经验是否有助于发现普通人群中的早期胰腺癌？

对普通人群进行癌症筛查是减少疾病负担的初级预防措施。虽然这对包括乳腺癌、结肠癌和前列腺癌在内的几种癌症来说是成功的，但筛查和预防胰腺癌的情况却不同。通过简单的身体检查或生物样本（粪便或血液检测）并不能检查出胰腺器官。血液检测如 PSA 也不具有成本效益。回顾胰腺癌高危人群筛查的证据，我们必须得出结论，由于缺乏适当的检测方法，目前没有理由对普通人群进行筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Familial Cancer 医学-遗传学

CiteScore

4.10

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： In recent years clinical cancer genetics has become increasingly important. Several events, in particular the developments in DNA-based technology, have contributed to this evolution. Clinical cancer genetics has now matured to a medical discipline which is truly multidisciplinary in which clinical and molecular geneticists work together with clinical and medical oncologists as well as with psycho-social workers. Due to the multidisciplinary nature of clinical cancer genetics most papers are currently being published in a wide variety of journals on epidemiology, oncology and genetics. Familial Cancer provides a forum bringing these topics together focusing on the interests and needs of the clinician. The journal mainly concentrates on clinical cancer genetics. Most major areas in the field shall be included, such as epidemiology of familial cancer, molecular analysis and diagnosis, clinical expression, treatment and prevention, counselling and the health economics of familial cancer.