Association between glycated albumin and sudden death in patients undergoing hemodialysis.

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY

Clinical and Experimental Nephrology Pub Date : 2024-07-01 Epub Date: 2024-03-04 DOI:10.1007/s10157-024-02475-w

Yoshiki Kaizu, Masaharu Nagata, Shinako Kaizu, Yueling Qie, Kazo Kaizu, Shigeru Tanaka, Toshiaki Nakano, Takanari Kitazono

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Abstract

Background: The frequency of sudden death and its risk factors in patients undergoing hemodialysis are unknown. This study was performed to examine the association between glycated albumin (GA) and sudden death in Japanese patients undergoing hemodialysis.

Methods: In total, 260 patients undergoing hemodialysis aged ≥18 years were retrospectively followed for a mean of 4.6 years. The patients' serum GA levels were divided into tertiles, and the patients' sex, age, albumin level, C-reactive protein (CRP) level, and cardiothoracic ratio (CTR) were selected as adjustment factors. A logistic regression model was used to calculate the odds ratio (OR) for the occurrence of sudden death by GA level.

Results: Ninety-one patients died during follow-up. Of the 91 deaths, 23 (25.2%) were defined as sudden deaths. Compared with non-sudden death cases, sudden death cases were significantly younger (p = 0.002) and had a higher proportion of men (p = 0.03), a higher proportion of diabetes (p = 0.008), and higher GA levels (p = 0.023). Compared with patients with the lowest GA levels (<15.2%), those with the highest GA levels (≥18.5%) had a sex- and age-adjusted OR for sudden death of 5.40 [95% confidence interval (CI): 1.35-21.85]. After adjusting for the albumin level, CRP level, and CTR in addition to sex and age, the OR for sudden death of patients with the highest GA levels increased to 6.80 (95%CI: 1.64-28.08); the relationship did not change.

Conclusion: Serum GA levels were significantly associated with sudden death in patients undergoing hemodialysis.

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血液透析患者糖化白蛋白与猝死之间的关系。

背景：血液透析患者猝死的频率及其风险因素尚不清楚。本研究旨在探讨日本血液透析患者糖化白蛋白（GA）与猝死之间的关系：方法：共对 260 名年龄≥18 岁的血液透析患者进行了平均 4.6 年的回顾性随访。将患者的血清 GA 水平分为三等分，并选择患者的性别、年龄、白蛋白水平、C 反应蛋白（CRP）水平和心胸比（CTR）作为调整因素。采用逻辑回归模型计算不同GA水平的猝死发生几率比（OR）：结果：91名患者在随访期间死亡。在 91 例死亡病例中，23 例（25.2%）被定义为猝死。与非猝死病例相比，猝死病例明显更年轻（p = 0.002），男性比例更高（p = 0.03），糖尿病比例更高（p = 0.008），GA水平更高（p = 0.023）。与 GA 含量最低的患者相比（结论：血清 GA 含量明显与糖尿病发病率相关），GA 含量最高的患者（结论：血清 GA 含量与糖尿病发病率相关血清 GA 水平与血液透析患者的猝死有明显相关性。

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来源期刊

Clinical and Experimental Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.10

自引率

4.30%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Clinical and Experimental Nephrology is a peer-reviewed monthly journal, officially published by the Japanese Society of Nephrology (JSN) to provide an international forum for the discussion of research and issues relating to the study of nephrology. Out of respect for the founders of the JSN, the title of this journal uses the term “nephrology,” a word created and brought into use with the establishment of the JSN (Japanese Journal of Nephrology, Vol. 2, No. 1, 1960). The journal publishes articles on all aspects of nephrology, including basic, experimental, and clinical research, so as to share the latest research findings and ideas not only with members of the JSN, but with all researchers who wish to contribute to a better understanding of recent advances in nephrology. The journal is unique in that it introduces to an international readership original reports from Japan and also the clinical standards discussed and agreed by JSN.