Diagnostic value of a novel salivary gland ultrasound scoring system in IgG4-related sialadenitis.

IF 4.7 2区医学 Q1 RHEUMATOLOGY

Rheumatology Pub Date : 2025-02-01 DOI:10.1093/rheumatology/keae121

Mingzhu Zhou, Yanying Liu, Shanshan Zhang, Xiaoyan Xie, Wei Li, Li Cui, Hanxue Zhao, Sumei Tang, Xiangdong Hu, Shanshan Wu, Jiajing Peng, Huilian Huang, Wei Ren, Ying Zhang, Ning Xu, Pengfei Sun, Yiqun Liu, Zuyan Zhang, Guangyan Yu, Yin Su

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引用次数: 0

Abstract

Objectives: To develop a novel ultrasound scoring system for the major salivary glands in patients with immunoglobulin G4-related sialadenitis (IgG4-RS) and assess its diagnostic value in a multicentre cohort of Chinese patients.

Methods: Twenty clinicians (rheumatologists, stomatologists and radiologists) participated. The study was conducted in four steps: (i) defining the ultrasonography (US) elements, (ii) developing a novel ultrasound scoring system for US of the salivary glands, (iii) evaluation of inter- and intra-reader reliabilities using the new ultrasound scoring system, and (iv) assessing the diagnostic value of this novel ultrasound scoring system in IgG4-RS patients in a Chinese multicentre cohort.

Results: A novel ultrasound scoring system for the salivary glands was developed, with total scores ranging from 0 to 34. The inter- and intra-reader reliabilities of the ultrasound scoring system were excellent (0.972 and 0.940, respectively). A total of 470 people were recruited in this study; 187 patients were diagnosed with IgG4-RS, and the remaining 283 people were diagnosed with non-IgG4-RS. Patients with IgG4-RS group had significantly higher US scores than the non-IgG4-RS group (mean US score = 16 vs 4, P < 0.001). The calculated area under the curve for the total US score was 0.852 (95% CI: 0.814, 0.891). The total US scores ≥9 showed a sensitivity of 75.4% and a specificity of 91.9%. Association analysis showed a positive correlation between total US scores and serum IgG4 levels and hypocomplementaemia (r = 0.221 and r = 0.349, respectively; P = 0.002 and P < 0.001, respectively) and a negative correlation between total US scores and serum C3 and C4 levels (r = -0.210 and r = -0.303, respectively; P = 0.005 and P < 0.001, respectively).

Conclusion: A novel semiquantitative ultrasound scoring system for patients with IgG4-RS was developed, with good diagnostic performance. The inter- and intra-reader reliabilities were excellent. US scores were correlated with IgG4, C3 and C4 levels and hypocomplementaemia.

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新型唾液腺超声评分系统对 IgG4 相关性唾液腺炎的诊断价值。

目的为免疫球蛋白 G4 相关性唾液腺炎（IgG4-RS）患者的主要唾液腺开发一种新型超声评分系统，并在中国患者的多中心队列中评估其诊断价值：20名临床医生（风湿免疫科医生、口腔科医生和放射科医生）参与了研究。研究分四个步骤进行：(1）定义超声波检查（US）要素；（2）开发新型唾液腺超声波检查评分系统；（3）使用新的超声波评分系统评估读片者之间和读片者内部的可靠性；（4）在中国多中心队列中评估该新型超声波评分系统对 IgG4-RS 患者的诊断价值：结果：针对唾液腺开发了一种新型超声评分系统，总分从 0 到 34 分不等。超声评分系统的读数间可靠性和读数内可靠性非常好（分别为 0.972 和 0.940）。本研究共招募了 470 人，其中 187 人被诊断为 IgG4-RS，其余 283 人被诊断为非 IgG4-RS。IgG4-RS患者的US评分明显高于非IgG4-RS组（平均US评分=16 vs. 4，P 结论：IgG4-RS患者的US评分明显高于非IgG4-RS组：针对IgG4-RS患者开发的新型半定量超声评分系统具有良好的诊断性能。阅卷人之间和阅卷人内部的可靠性都很好。超声评分与 IgG4、C3 和 C4 水平及低补体血症相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

7.30%

发文量

1091

审稿时长

2 months

期刊介绍： Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press. Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.