Erythronecroptosis: an overview of necroptosis or programmed necrosis in red blood cells.

IF 3.5 2区 生物学 Q3 CELL BIOLOGY
Molecular and Cellular Biochemistry Pub Date : 2024-12-01 Epub Date: 2024-03-01 DOI:10.1007/s11010-024-04948-8
Anton Tkachenko, Ondrej Havranek
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引用次数: 0

Abstract

Necroptosis is considered a programmed necrosis that requires receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3), and pore-forming mixed lineage kinase domain-like protein (MLKL) to trigger a regulated cell membrane lysis. Membrane rupture in necroptosis has been shown to fuel innate immune response due to release of damage-associated molecular patterns (DAMPs). Recently published studies indicate that mature erythrocytes can undergo necroptosis as well. In this review, we provide an outline of multiple cell death modes occurring in erythrocytes, discuss possible immunological aspects of diverse erythrocyte cell deaths, summarize available evidence related to the ability of erythrocytes to undergo necroptosis, outline key involved molecular mechanisms, and discuss the potential implication of erythrocyte necroptosis in the physiology and pathophysiology. Furthermore, we aim to highlight the interplay between necroptosis and eryptosis signaling in erythrocytes, emphasizing specific characteristics of these pathways distinct from their counterparts in nucleated cells. Thus, our review provides a comprehensive summary of the current knowledge of necroptosis in erythrocytes. To reflect critical differences between necroptosis of nucleated cells and necroptosis of erythrocytes, we suggest a term erythronecroptosis for necroptosis of enucleated cells.

红细胞坏死:红细胞坏死或程序性坏死概述。
坏死被认为是一种程序性坏死,需要受体相互作用蛋白激酶 1(RIPK1)、受体相互作用蛋白激酶 3(RIPK3)和孔形成混合系激酶结构域样蛋白(MLKL)来触发调节性细胞膜裂解。研究表明,坏死过程中的细胞膜破裂会因损伤相关分子模式(DAMPs)的释放而激发先天性免疫反应。最近发表的研究表明,成熟红细胞也会发生坏死。在这篇综述中,我们概述了红细胞的多种细胞死亡模式,讨论了多种红细胞死亡可能涉及的免疫学问题,总结了与红细胞坏死能力有关的现有证据,概述了其中涉及的关键分子机制,并讨论了红细胞坏死在生理学和病理生理学中的潜在影响。此外,我们还旨在强调红细胞坏死和红细胞凋亡信号之间的相互作用,强调这些途径不同于有核细胞中相应途径的具体特征。因此,我们的综述全面总结了目前有关红细胞坏死的知识。为了反映有核细胞坏死与红细胞坏死之间的关键差异,我们建议将有核细胞坏死称为红细胞坏死。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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