Aldosterone Effect on Cardiac Structure and Function.

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Ekhlas Mahmoud Al-Hashedi, Fuad A Abdu
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引用次数: 0

Abstract

Background: Cardiac remodelling could be a key mechanism in aldosteronemediated cardiovascular morbidity and mortality. Experimental and clinical evidence has demonstrated that aldosterone causes cardiac structural remodelling and dysfunction by its profibrotic and pro-hypertrophic effects, which result mainly from the direct effects on myocardial collagen deposition, inflammation, and oxidative stress. Clinical studies have investigated the aldosterone effects on the heart in different clinical conditions, including general population, essential hypertension, primary aldosteronism, heart failure, and atrial fibrillation. Robust findings indicate that aldosterone or the activation of the cardiac mineralocorticoid receptor can cause damage to myocardial tissue by mechanisms independent of the blood pressure, leading to tissue hypertrophy, fibrosis, and dysfunction.

Conclusion: Aldosterone-mediated cardiovascular morbidity and mortality mainly result from cardiac structural and functional alterations. In different clinical settings, aldosterone can induce cardiac structural remodelling and dysfunction via several pathological mechanisms, including cardiac fibrosis, inflammation, and oxidative stress. Aldosterone antagonists could effectively decrease or reverse the detrimental aldosterone-mediated changes in the heart.

醛固酮对心脏结构和功能的影响
背景:心脏重塑可能是醛固酮导致心血管疾病发病和死亡的一个关键机制。实验和临床证据表明,醛固酮通过其促破损和促肥厚作用导致心脏结构重塑和功能障碍,这些作用主要来自于对心肌胶原沉积、炎症和氧化应激的直接影响。临床研究调查了醛固酮在不同临床条件下对心脏的影响,包括普通人群、原发性高血压、原发性醛固酮增多症、心力衰竭和心房颤动。大量研究结果表明,醛固酮或心脏矿质皮质激素受体的激活可通过与血压无关的机制对心肌组织造成损害,导致组织肥厚、纤维化和功能障碍:醛固酮介导的心血管疾病发病率和死亡率主要源于心脏结构和功能的改变。在不同的临床环境中,醛固酮可通过多种病理机制诱导心脏结构重塑和功能障碍,包括心脏纤维化、炎症和氧化应激。醛固酮拮抗剂可有效减少或逆转醛固酮介导的心脏有害变化。
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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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