Increased skeletal muscle mass index was involved in glycemic efficacy following diabetes treatment, and changes in fat mass index correlated with the changes in the lipid ratio in type 2 diabetes

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-02-27 DOI:10.1016/j.jdiacomp.2024.108717

Shun Matsuura , Soichiro Nagata , Koji Shibazaki , Reiko Uchida , Yukiko Imai , Shoko Shibata , Hiroshi Morita

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Abstract

Aim

This study aimed to investigate the association between changes in body composition, glycated hemoglobin, and lipid ratio during the treatment of patients with type 2 diabetes mellitus (T2DM).

Methods

This retrospective analysis used data from outpatients with T2DM who had confirmed body composition and measured laboratories at administration and after treatment. The baseline characteristics and prescribed treatment were collected. The total cholesterol/high-density lipoprotein cholesterol (HDL) ratio, low-density lipoprotein cholesterol (LDL)/HDL ratio, and triglyceride–glucose (TyG) index were also calculated.

Results

A total of 207 patients (mean patient age, 62.0 ± 13.7 years; 68.1 % males) were enrolled. Fat mass index (FMI) changes correlated with the changes in the lipid ratio, whereas skeletal muscle mass index (SMI) changes inversely correlated with glycated hemoglobin (HbA1c) changes. Multiple regression analysis showed that changes in LDL/HDL and TyG correlated with FMI changes (t = 2.388, p = 0.017, t = 2.022, p = 0.044). Conversely, HbA1c changes correlated with SMI changes (t = −2.552, p = 0.011).

Conclusion

In patients with T2DM, increased SMI was involved in glycemic efficacy, and FMI changes were associated with LDL/HDL and TyG.

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骨骼肌质量指数的增加与糖尿病治疗后的血糖疗效有关，脂肪质量指数的变化与 2 型糖尿病患者血脂比率的变化有关

本研究旨在探讨 2 型糖尿病（T2DM）患者治疗期间身体成分、糖化血红蛋白和血脂比率变化之间的关联。收集了基线特征和处方治疗。还计算了总胆固醇/高密度脂蛋白胆固醇（HDL）比率、低密度脂蛋白胆固醇（LDL）/HDL 比率和甘油三酯-葡萄糖（TyG）指数。脂肪质量指数（FMI）的变化与血脂比率的变化相关，而骨骼肌质量指数（SMI）的变化与糖化血红蛋白（HbA1c）的变化成反比。多元回归分析表明，低密度脂蛋白/高密度脂蛋白和 TyG 的变化与 FMI 的变化相关（t = 2.388，p = 0.017；t = 2.022，p = 0.044）。结论在 T2DM 患者中，SMI 的增加与血糖疗效有关，而 FMI 的变化与 LDL/HDL 和 TyG 有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.

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