P2X7 receptors: a bibliometric review from 2002 to 2023.

IF 2.4 4区医学 Q2 NEUROSCIENCES

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-02-29 DOI:10.1007/s11302-024-09996-9

Haiting Tang, Wei Wei, Yu Luo, Xiaoqing Lu, Jun Chen, Shenqiao Yang, Fei Wu, Haiyan Zhou, Wenbin Ma, Xin Yang

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引用次数: 0

Abstract

For many years, there has been ongoing research on the P2X7 receptor (P2X7R). A comprehensive, systematic, and objective evaluation of the scientific output and status of P2X7R will be instrumental in guiding future research directions. This study aims to present the status and trends of P2X7R research from 2002 to 2023. Publications related to P2X7R were retrieved from the Web of Science Core Collection database. Quantitative analysis and visualization tools were Microsoft Excel, VOSviewer, and CiteSpace software. The analysis content included publication trends, literature co-citation, and keywords. 3282 records were included in total, with the majority of papers published within the last 10 years. Based on literature co-citation and keyword analysis, neuroinflammation, neuropathic pain, gastrointestinal diseases, tumor microenvironment, rheumatoid arthritis, age-related macular degeneration, and P2X7R antagonists were considered to be the hotspots and frontiers of P2X7R research. Researchers will get a more intuitive understanding of the status and trends of P2X7R research from this study.

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P2X7 受体：2002 年至 2023 年文献计量学回顾。

多年来，有关 P2X7 受体（P2X7R）的研究一直在进行。对 P2X7R 的科研成果和现状进行全面、系统和客观的评估将有助于指导未来的研究方向。本研究旨在介绍 2002 年至 2023 年 P2X7R 的研究现状和趋势。与 P2X7R 相关的论文均从 Web of Science Core Collection 数据库中检索。定量分析和可视化工具为 Microsoft Excel、VOSviewer 和 CiteSpace 软件。分析内容包括发表趋势、文献共引和关键词。共收录了 3282 条记录，其中大部分论文发表于最近 10 年内。根据文献共引和关键词分析，神经炎症、神经病理性疼痛、胃肠道疾病、肿瘤微环境、类风湿性关节炎、老年性黄斑变性和P2X7R拮抗剂被认为是P2X7R研究的热点和前沿。研究人员将从本研究中更直观地了解 P2X7R 的研究现状和趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Purinergic Signalling 医学-神经科学

CiteScore

6.60

自引率

17.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.