Association between sex and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis.

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI:10.2217/imt-2023-0307

Jianxiong Lai, Xiaohong Kuang, Yi Fu, Jian Li

引用次数: 0

Abstract

Aim: To explore the association between sex and immune checkpoint inhibitors (ICIs). Materials & methods: We assessed the difference in survival outcomes from ICIs between sexes using an interaction test. Results: 108 studies representing 70,243 patients were included. In the first-line setting, the pooled interaction HR was 0.97 (95% CI: 0.91-1.04). In the subsequent-line setting, the pooled interaction HR was 0.85 (95% CI: 0.77-0.95). When ICIs were given as perioperative therapy or as systemic therapy in patients with positive PD-L1 expression, both men and women obtained equal survival benefits. Conclusion: Both sex, line of therapy, cancer (sub)type and PD-L1 status should be taken into account in the assessment of risk versus benefit when deciding to offer ICIs to patients.

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性别与免疫检查点抑制剂疗效之间的关系：系统综述与荟萃分析。

目的：探讨性别与免疫检查点抑制剂（ICIs）之间的关系。材料与方法我们使用交互检验法评估了不同性别在使用 ICIs 后的生存结果差异。结果共纳入 108 项研究，代表 70,243 名患者。在一线治疗中，汇总的交互作用 HR 为 0.97（95% CI：0.91-1.04）。在随后的一线治疗中，汇总的交互 HR 为 0.85（95% CI：0.77-0.95）。在PD-L1表达阳性的患者中，如果将ICIs作为围手术期治疗或全身治疗，男性和女性都能获得相同的生存获益。结论在决定为患者提供 ICIs 时，在评估风险与获益时应考虑性别、治疗方案、癌症（亚）类型和 PD-L1 状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.