Dual-targeted CAR T-cell immunotherapies for hematological malignancies: latest updates from the 2023 ASH annual meeting

IF 9.4 1区医学 Q1 HEMATOLOGY

Experimental Hematology & Oncology Pub Date : 2024-02-27 DOI:10.1186/s40164-024-00485-8

Jingyi Yang, Hao Guo, Lu Han, Yongping Song, Keshu Zhou

引用次数: 0

Abstract

Over the past few years, dual-targeted chimeric antigen receptor (CAR) T-cell therapy has been employed in the management of hematological malignancies to mitigate treatment failure, particularly in cases of antigen escape. The most widely used approaches include CD19/CD20, CD20/CD22, and BCMA/CD19 CAR T-cells. Alternative immune cells, including natural killer T cells and invariant natural killer T cells, exhibit innate anti-tumor activity and reduced toxicity. This review summarizes several recent clinical trial reports and preclinical studies from the 2023 American Society of Hematology (ASH) annual meeting on dual-targeted CAR T-cell immunotherapy for hematological malignancies.

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治疗血液恶性肿瘤的双靶向 CAR T 细胞免疫疗法：2023 年 ASH 年会的最新进展

在过去几年中，双靶点嵌合抗原受体（CAR）T细胞疗法已被用于血液恶性肿瘤的治疗，以缓解治疗失败，尤其是在抗原逃逸的情况下。使用最广泛的方法包括 CD19/CD20、CD20/CD22 和 BCMA/CD19 CAR T 细胞。替代性免疫细胞，包括自然杀伤 T 细胞和不变自然杀伤 T 细胞，表现出先天性抗肿瘤活性并降低毒性。本综述总结了 2023 年美国血液学会（ASH）年会上有关血液恶性肿瘤双靶向 CAR T 细胞免疫疗法的几项最新临床试验报告和临床前研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Hematology & Oncology Medicine-Oncology

CiteScore

12.60

自引率

7.30%

发文量

审稿时长

6 weeks

期刊介绍： Experimental Hematology & Oncology is an open access journal that encompasses all aspects of hematology and oncology with an emphasis on preclinical, basic, patient-oriented and translational research. The journal acts as an international platform for sharing laboratory findings in these areas and makes a deliberate effort to publish clinical trials with 'negative' results and basic science studies with provocative findings. Experimental Hematology & Oncology publishes original work, hypothesis, commentaries and timely reviews. With open access and rapid turnaround time from submission to publication, the journal strives to be a hub for disseminating new knowledge and discussing controversial topics for both basic scientists and busy clinicians in the closely related fields of hematology and oncology.