O-14 NON-ALCOHOLIC FATTY LIVER DISEASE IS INFLUENCED BY THE INTERACTION OF HELICOBACTER PYLORI INFECTION AND G-ALLELE OF PNPLA3

IF 3.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Facundo Maiorana , Magalí Neschuk , María Virginia Caronia , Adolfo Schneider , Georgina Veron , Pedro Dario Zapata , Fernando Javier Barreyro
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引用次数: 0

Abstract

Introduction and Objectives

The pathophysiology of NAFLD is only partially unrevealed; it is considered as a multifactorial disorder, attributed to multiple, parallel “hits,” both genetic and environmental. It has been described that the single nucleotide polymorphism at rs738409 in the PNPLA3 gene is strongly associated with hepatic steatosis and its progression. Conversely, H. pylori infection has been related to metabolic syndrome, type-2 diabetes mellitus, and dyslipidemia, which are known risk factors for NAFLD. However, the evaluation of Infection and the rs738409 polymorphism in the PNPLA3 gene has not been explored.

Materials and Methods

this is a preliminary report of a prospective multicenter study from December 2020 to June 2021 in northeastern Argentina. 76 dyspeptic adult patients who fulfilled the ROME-IV criteria and underwent gastroscopy, of which 69 were included. The presence of H. pylori was determined by gastric histology. Biochemical and clinical parameters were recorded. NAFLD was defined by liver ultrasonography. The PNPLA3 gene was analyzed by PCR-RFLP in rs738409.

Results

The prevalence of NAFLD was 45% (31/69), with Hpyl+ 48% (17/36) and Hpyl- 42% (14/33) (p: ns). The variables significantly associated with NAFLD were BMI, dyslipidemia, Diabetes/prediabetes, presence of the G allele of PNPLA3, and the GG genotype. In the multivariate analysis, BMI (OR 1.63 95%CI 1.22-2.19) and the G-allele of PNPLA3 (OR 7.35 95%CI 1.34-40) were independently associated with NAFLD. When subjects with NAFLD were analyzed, the interaction between Hpyl and PNPLA3 allele-G was significantly associated with NAFLD (65%) and increased risk of liver fibrosis (FIB-4 > 1.3 41%).

Conclusions

the presence of NAFLD was associated with BMI and G-allele of PNPLA3. The combination of Hpyl infection and the G-allele of PNPLA3 were associated with NAFLD and risk of fibrosis (FIB-4)

o-14 非酒精性脂肪肝受幽门螺杆菌感染和 pnpla3 的 g-等位基因相互作用的影响
导言和目的:非酒精性脂肪肝的病理生理学尚未完全揭示;它被认为是一种多因素疾病,是由遗传和环境等多重并行 "打击 "造成的。有研究表明,PNPLA3 基因的单核苷酸多态性 rs738409 与肝脏脂肪变性及其进展密切相关。相反,幽门螺杆菌感染与代谢综合征、2 型糖尿病和血脂异常等非酒精性脂肪肝的已知危险因素有关。材料与方法这是 2020 年 12 月至 2021 年 6 月在阿根廷东北部进行的一项前瞻性多中心研究的初步报告。纳入了符合 ROME-IV 标准并接受胃镜检查的 76 名消化不良成人患者,其中 69 名患者接受了胃镜检查。通过胃组织学检查确定是否存在幽门螺杆菌。生化和临床参数均有记录。非酒精性脂肪肝是通过肝脏超声波检查确定的。通过 PCR-RFLP 分析了 PNPLA3 基因的 rs738409。结果非酒精性脂肪肝的患病率为 45%(31/69),其中 Hpyl+ 占 48%(17/36),Hpyl- 占 42%(14/33)(P:ns)。与非酒精性脂肪肝明显相关的变量有体重指数、血脂异常、糖尿病/再糖尿病、PNPLA3 的 G 等位基因和 GG 基因型。在多变量分析中,体重指数(OR 1.63 95%CI 1.22-2.19)和 PNPLA3 的 G 等位基因(OR 7.35 95%CI 1.34-40)与非酒精性脂肪肝独立相关。在对患有非酒精性脂肪肝的受试者进行分析时,Hpyl 和 PNPLA3 等位基因-G 之间的相互作用与非酒精性脂肪肝(65%)和肝纤维化风险增加(FIB-4 >;1.3 41%)显著相关。Hpyl感染和PNPLA3的G-等位基因组合与非酒精性脂肪肝和肝纤维化风险(FIB-4)相关。
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来源期刊
Annals of hepatology
Annals of hepatology 医学-胃肠肝病学
CiteScore
7.90
自引率
2.60%
发文量
183
审稿时长
4-8 weeks
期刊介绍: Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.
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