Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization

IF 5.4 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

International endodontic journal Pub Date : 2024-02-27 DOI:10.1111/iej.14034

Yuqiang Wang, Jiakang Zhu, Ying Tang, Cui Huang

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引用次数: 0

Abstract

Aim

This current Mendelian randomization (MR) study aims to comprehensively explore the potential bidirectional link between pulp and periapical disease (PAP) with type 2 diabetes mellitus (T2DM).

Methodology

Summary level data of European-based population genome-wide association studies (GWASs) were employed to undertake this MR study. With the selection of single nucleotide polymorphisms (SNPs) as the instrumental variable, the radial inverse-variance weighted (radial IVW) method with modified second-order weights was applied as the primary method. Additionally, a range of sensitivity analyses were conducted to investigate pleiotropy. Results from different sources of outcome were pooled by meta-analysis with the fixed model.

Results

The results of this MR analysis did not suggest a significant impact of pulp and periapical disease on type 2 diabetes (combined OR = 1.04, 95% CI: 1.00–1.07, p = .033) and vice versa (OR = 1.04, 95% CI: 0.96–1.14, p = .329). No significant pleiotropy was detected in the final model after the removal of outliers, demonstrating the reliability of the results in our primary analysis.

Conclusions

With the limitations inherent in the present MR study, there is no significant evidence in either direction to suggest a causal association between pulp and periapical disease and type 2 diabetes mellitus.

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牙髓和根尖周病与 2 型糖尿病的关系：双向孟德尔随机试验

目的：本项孟德尔随机化（MR）研究旨在全面探讨牙髓和根尖周病（PAP）与 2 型糖尿病（T2DM）之间的潜在双向联系：本研究采用了基于欧洲人群的全基因组关联研究（GWAS）的汇总数据。在选择单核苷酸多态性（SNPs）作为工具变量的情况下，采用了带有修正二阶权重的径向逆方差加权法（radial IVW）作为主要方法。此外，还进行了一系列敏感性分析，以研究多效性。采用固定模型进行荟萃分析，对不同结果来源的结果进行汇总：MR分析结果表明，牙髓和根尖周疾病对2型糖尿病没有显著影响（合并OR = 1.04，95% CI：1.00-1.07，p = .033），反之亦然（OR = 1.04，95% CI：0.96-1.14，p = .329）。剔除异常值后，最终模型中未发现明显的多向性，这表明我们的主要分析结果是可靠的：尽管本磁共振研究存在固有的局限性，但没有明显证据表明牙髓和根尖周病与 2 型糖尿病之间存在因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International endodontic journal 医学-牙科与口腔外科

CiteScore

10.20

自引率

28.00%

发文量

195

审稿时长

4-8 weeks

期刊介绍： The International Endodontic Journal is published monthly and strives to publish original articles of the highest quality to disseminate scientific and clinical knowledge; all manuscripts are subjected to peer review. Original scientific articles are published in the areas of biomedical science, applied materials science, bioengineering, epidemiology and social science relevant to endodontic disease and its management, and to the restoration of root-treated teeth. In addition, review articles, reports of clinical cases, book reviews, summaries and abstracts of scientific meetings and news items are accepted. The International Endodontic Journal is essential reading for general dental practitioners, specialist endodontists, research, scientists and dental teachers.