Obesity is associated with long-term outcome of catheter ablation of atrial fibrillation in patients with dilated cardiomyopathy.

IF 0.7 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Journal of Africa Pub Date : 2024-02-20 DOI:10.5830/CVJA-2023-063

Jiaqi Yang, Tienan Sun, Xunxun Feng, Yuchao Zhang, Biyang Zhang, Yang Liu, Qianyun Guo

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引用次数: 0

Abstract

Background: Patients with atrial fibrillation (AF) and dilated cardiomyopathy (DCM) often exhibit cardiac dysfunction and a poor prognosis. However, the specific reasons are unclear. This study aimed to describe the impact of obesity in patients with AF and DCM.

Methods: Seventy-four consecutive patients with AF and DCM were enrolled and classified by body mass index. We measured primary endpoints, including cardiac death, recurrent AF, recurrent atrial tachyarrhythmia and stroke, as well as secondary endpoints.

Results: In multivariate analysis, compared to the normal-weight group, the overweight and obese groups had greater incidences of recurrent AF (0.0 vs 30.3 vs 40.0%, respectively, log-rank p = 0.048) and rehospitalisation (9.1 vs 36.4 vs 45.0%, respectively, log-rank p = 0.035). Compared to the normal-weight group, five-year outcomes for primary endpoints were inferior in the overweight and obese groups (18.2 vs 30.3 vs 50.0%, respectively, log-rank p = 0.042). Overweight patients exhibited more benefit in recovery of left ventricular ejection fraction after ablation (from 39.1 to 50.0%, p = 0.005) than the normal-weight group (from 43.1 to 52.3%, p = 0.199) and obese group (from 44.9 to 51.2%, p = 0.216).

Conclusion: Patients with AF and DCM with overweight or obesity exhibited worse long-term outcomes in recurrent AF than normal-weight patients. However, overweight patients showed the most benefit in cardiac function after ablation.

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肥胖与扩张型心肌病患者心房颤动导管消融术的长期疗效有关。

背景：心房颤动（房颤）和扩张型心肌病（DCM）患者通常表现出心功能不全和预后不良。然而，具体原因尚不清楚。本研究旨在描述肥胖对房颤和扩张型心肌病患者的影响：方法：我们连续招募了 74 名房颤和 DCM 患者，并按体重指数进行了分类。我们测量了主要终点，包括心源性死亡、复发性房颤、复发性房性快速心律失常和中风，以及次要终点：在多变量分析中，与正常体重组相比，超重组和肥胖组的复发性房颤（分别为 0.0 vs 30.3 vs 40.0%，log-rank p = 0.048）和再住院（分别为 9.1 vs 36.4 vs 45.0%，log-rank p = 0.035）发生率更高。与正常体重组相比，超重组和肥胖组主要终点的五年疗效较差（分别为 18.2 vs 30.3 vs 50.0%，log-rank p = 0.042）。与正常体重组（从43.1%到52.3%，P = 0.199）和肥胖组（从44.9%到51.2%，P = 0.216）相比，超重患者在消融后左室射血分数恢复方面获益更大（从39.1%到50.0%，P = 0.005）：结论：与正常体重患者相比，超重或肥胖的房颤和 DCM 患者复发房颤的长期预后较差。结论：超重或肥胖的房颤和先天性心脏病患者复发房颤的长期预后比正常体重患者差，但超重患者在消融术后的心脏功能获益最大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Journal of Africa CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cardiovascular Journal of Africa (CVJA) is an international peer-reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. Topics covered include coronary disease, electrophysiology, valve disease, imaging techniques, congenital heart disease (fetal, paediatric and adult), heart failure, surgery, and basic science.