Dysregulated CXCL12 expression in osteoblasts promotes B-lymphocytes preferentially homing to the bone marrow in MRL/lpr mice

IF 3.3 4区医学 Q3 IMMUNOLOGY

Autoimmunity Pub Date : 2024-02-25 DOI:10.1080/08916934.2024.2319207

Wenjuan Zheng, Yu Tang, Mengwei Cheng, Cui Ma, Xiaoming Fei, Wei Shi

引用次数: 0

Abstract

Objective: Todetect the abnormal distribution of B-lymphocytes between peripheral and bone marrow (BM) compartments and explore the mechanism of abnormal chemotaxis of B-lymphocytes in lupus subjec...

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成骨细胞中表达失调的 CXCL12 可促进 B 淋巴细胞优先归巢到 MRL/lpr 小鼠的骨髓中

目的检测狼疮患者B淋巴细胞在外周和骨髓（BM）间的异常分布，并探讨B淋巴细胞异常趋化的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity 医学-免疫学

CiteScore

5.70

自引率

8.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Autoimmunity is an international, peer reviewed journal that publishes articles on cell and molecular immunology, immunogenetics, molecular biology and autoimmunity. Current understanding of immunity and autoimmunity is being furthered by the progress in new molecular sciences that has recently been little short of spectacular. In addition to the basic elements and mechanisms of the immune system, Autoimmunity is interested in the cellular and molecular processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, type I diabetes, multiple sclerosis and other systemic and organ-specific autoimmune disorders. The journal reflects the immunology areas where scientific progress is most rapid. It is a valuable tool to basic and translational researchers in cell biology, genetics and molecular biology of immunity and autoimmunity.