EXTRACTION TIME EFFECT ON ACTIVE COMPOUNDS LEVELS IN CAT WHISKERS (ORTHOSIPHON ARISTATUS (BLUME) MIQ.)

Q2 Pharmacology, Toxicology and Pharmaceutics

International Journal of Applied Pharmaceutics Pub Date : 2024-02-15 DOI:10.22159/ijap.2024.v16s1.01

Fahrauk Faramayuda, S. Riyanti, Suryani, Shindi Juni Karmila, A. S. Windyaswari, Rizka Khoirunnisa Guntina

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引用次数: 0

Abstract

Objective: Determine the best time to boil cat whiskers by observing the impact of boiling time on the quantities of rosmarinic acid in cat whiskers. Methods: For the extraction process, water is boiled for 10, 20, and 30 min at 90 degrees Celsius. High-Performance Liquid Chromatography (HPLC) was used to measure the quantities of rosmarinic acid and validate the analytical procedures in terms of accuracy, precision, linearity, and specificity. The one-way ANOVA test and Duncan's test were used to analyse the data; a p-value of 0.05 was used to indicate a statistically significant difference. Results: The lowest quantities of rosmarinic acid were found in the study's results during a shorter boiling duration of 10 min, or 2.07% w/w. The highest concentrations of rosmarinic acid were found after a prolonged boiling period of 20 min, at 2.32 % w/w. Meanwhile, rosmarinic acid levels dropped to 2.15 % w/w after a 30 min overboiling period. Rosmarinic acid levels from the three boiling durations differed significantly, according to statistical analysis (p=0.000; p<0.05). Conclusion: It was determined that 20 min was the ideal boiling duration for extracting rosmarinic acid from purple cat whiskers.

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提取时间对猫须（orthosiphon aristatus (blume) miq.）

目标：通过观察煮沸时间对猫须中迷迭香酸含量的影响，确定煮沸猫须的最佳时间。方法在提取过程中，将水在 90 摄氏度下煮沸 10、20 和 30 分钟。采用高效液相色谱法（HPLC）测定迷迭香酸的含量，并从准确度、精密度、线性度和特异性等方面验证分析程序。数据分析采用了单因素方差分析和邓肯检验，以 p 值 0.05 为差异有统计学意义。结果在较短的沸腾时间（10 分钟）内，研究结果中发现的迷迭香酸含量最低，为 2.07% w/w。在长时间煮沸 20 分钟后，发现的迷迭香酸浓度最高，为 2.32% w/w。同时，经过 30 分钟的过度煮沸后，香豆酸的浓度下降到 2.15 % w/w。根据统计分析，三种煮沸时间的迷迭香酸含量差异显著（p=0.000；p<0.05）。结论经测定，20 分钟是从紫猫须中提取迷迭香酸的理想煮沸时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Applied Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

219

期刊介绍： International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly (onward March 2017) open access journal devoted to the excellence and research in the pure pharmaceutics. This Journal publishes original research work that contributes significantly to further the scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier based drug delivery, novel routes and modes of delivery; responsive delivery systems, prodrug design, development and characterization of the targeted drug delivery systems, ligand carrier interactions etc. However, the other areas which are related to the pharmaceutics are also entertained includes physical pharmacy and API (active pharmaceutical ingredients) analysis. The Journal publishes original research work either as a Original Article or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication in the Journal.