Association of CSF biomarkers with MRI brain changes in Alzheimer's disease

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring Pub Date : 2024-02-23 DOI:10.1002/dad2.12556

Nazib Seidu, S. Kern, S. Sacuiu, T. R. Sterner, K. Blennow, Henrik Zetterberg, O. Lindberg, D. Ferreira, Eric Westman, A. Zettergren, Ingmar Skoog

{"title":"Association of CSF biomarkers with MRI brain changes in Alzheimer's disease","authors":"Nazib Seidu, S. Kern, S. Sacuiu, T. R. Sterner, K. Blennow, Henrik Zetterberg, O. Lindberg, D. Ferreira, Eric Westman, A. Zettergren, Ingmar Skoog","doi":"10.1002/dad2.12556","DOIUrl":null,"url":null,"abstract":"Abstract The relation between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures is poorly understood in cognitively healthy individuals from the general population. Participants’ (n = 226) mean age was 70.9 years (SD = 0.4). CSF concentrations of amyloid beta (Aβ)1‐42, total tau (t‐tau), phosphorylated tau (p‐tau), neurogranin, and neurofilament light, and volumes of hippocampus, amygdala, total basal forebrain (TBF), and cortical thickness were measured. Linear associations between CSF biomarkers and MRI measures were investigated. In Aβ1‐42 positives, higher t‐tau and p‐tau were associated with smaller hippocampus (P = 0.001 and P = 0.003) and amygdala (P = 0.005 and P = 0.01). In Aβ1‐42 negatives, higher t‐tau, p‐tau, and neurogranin were associated with larger TBF volume (P = 0.001, P = 0.001, and P = 0.01). No associations were observed between the CSF biomarkers and an AD signature score of cortical thickness. AD‐specific biomarkers in cognitively healthy 70‐year‐olds may be related to TBF, hippocampus, and amygdala. Lack of association with cortical thickness might be due to early stage of disease.","PeriodicalId":516929,"journal":{"name":"Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring","volume":"12 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dad2.12556","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract The relation between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures is poorly understood in cognitively healthy individuals from the general population. Participants’ (n = 226) mean age was 70.9 years (SD = 0.4). CSF concentrations of amyloid beta (Aβ)1‐42, total tau (t‐tau), phosphorylated tau (p‐tau), neurogranin, and neurofilament light, and volumes of hippocampus, amygdala, total basal forebrain (TBF), and cortical thickness were measured. Linear associations between CSF biomarkers and MRI measures were investigated. In Aβ1‐42 positives, higher t‐tau and p‐tau were associated with smaller hippocampus (P = 0.001 and P = 0.003) and amygdala (P = 0.005 and P = 0.01). In Aβ1‐42 negatives, higher t‐tau, p‐tau, and neurogranin were associated with larger TBF volume (P = 0.001, P = 0.001, and P = 0.01). No associations were observed between the CSF biomarkers and an AD signature score of cortical thickness. AD‐specific biomarkers in cognitively healthy 70‐year‐olds may be related to TBF, hippocampus, and amygdala. Lack of association with cortical thickness might be due to early stage of disease.

查看原文本刊更多论文

脑脊液生物标志物与阿尔茨海默病核磁共振成像脑部变化的关系

摘要在认知能力健康的普通人群中，阿尔茨海默病（AD）的脑脊液（CSF）生物标志物与磁共振成像（MRI）测量之间的关系尚不清楚。参与者（n = 226）的平均年龄为 70.9 岁（SD = 0.4）。研究人员测量了CSF中淀粉样β（Aβ）1-42、总tau（t-tau）、磷酸化tau（p-tau）、神经粒蛋白和神经丝光的浓度，以及海马、杏仁核、前脑总基底（TBF）和皮层厚度的体积。研究了 CSF 生物标志物与 MRI 测量之间的线性关系。在 Aβ1-42 阳性者中，较高的 t-tau 和 p-tau 与较小的海马（P = 0.001 和 P = 0.003）和杏仁核（P = 0.005 和 P = 0.01）相关。在 Aβ1-42 阴性患者中，较高的 t-tau、p-tau 和神经粒蛋白与较大的 TBF 体积相关（P = 0.001、P = 0.001 和 P = 0.01）。CSF生物标志物与皮质厚度的AD特征性评分之间没有关联。认知健康的70岁老人的AD特异性生物标志物可能与TBF、海马和杏仁核有关。与皮质厚度缺乏关联可能是由于疾病处于早期阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

自引率

0.00%

发文量