Recreational Nitrous Oxide Dosing and Administration and Its Use in Traffic: An Online Survey

IF 1.2 4区社会学 Q4 SUBSTANCE ABUSE

Journal of Drug Issues Pub Date : 2024-02-24 DOI:10.1177/00220426241233193

Frederick Vinckenbosch, Eef Theunissen, Agnieszka Stelling, Charles Goldenbeld, Johannes G. Ramaekers

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引用次数: 0

Abstract

Nitrous oxide (N2O) is a popular recreational intoxicant and associated paraphernalia are increasingly being found at road traffic accident scenes in the Netherlands, suggesting that N2O intoxication causally contributes to the occurrence of a significant number of road traffic accidents. However, information on the pharmacodynamics- and kinetic characteristics of recreational N2O use is limited, impeding policy making and enforcement. This investigation aimed to determine a representative dosing method for recreational N2O use and establish a relevant timeframe for assessing psychomotoric functioning in future research. Online survey responses of 511 N2O users revealed that the majority inhaled N2O from party balloons filled with 4–14 L of N2O. Inhalation typically involved a repetitive “rebreathing” technique with 20–30 second breaks every six cycles, or without breaks, for approximately 12 cycles in total. 10.3% of respondents admitted to have inhaled N2O during driving in the past. Driving departure within 1 hour of inhalation was common, providing a relevant timeframe for the investigation of psychomotoric effects of recreational N2O use in future research.

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娱乐性一氧化二氮的剂量和管理及其在交通中的使用：在线调查

一氧化二氮（N2O）是一种流行的娱乐性麻醉剂，在荷兰的道路交通事故现场，越来越多地发现了与之相关的用具，这表明一氧化二氮中毒是导致大量道路交通事故发生的原因之一。然而，有关娱乐性使用一氧化二氮的药效学和动力学特征的信息十分有限，这阻碍了政策的制定和执行。这项调查旨在确定娱乐性使用一氧化二氮的代表性剂量方法，并为未来研究中的精神动力功能评估确定相关的时间框架。对 511 名一氧化二氮使用者进行的在线调查显示，大多数人从装有 4-14 升一氧化二氮的派对气球中吸入一氧化二氮。吸入通常采用重复的 "再吸气 "技术，每六个周期休息 20-30 秒，或不休息，总共约 12 个周期。10.3% 的受访者承认过去曾在驾驶过程中吸入过一氧化二氮。在吸入后 1 小时内驾车离开的情况很普遍，这为今后调查娱乐性使用一氧化二氮的精神作用提供了相关的时间范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Drug Issues SUBSTANCE ABUSE-

CiteScore

3.00

自引率

11.80%

发文量

期刊介绍： The Journal of Drug Issues (JDI) was incorporated as a nonprofit entity in the State of Florida in 1971. In 1996, JDI was transferred to the Florida State University College of Criminology and Criminal Justice, and the Richard L. Rachin Endowment was established to support its continued publication. Since its inception, JDI has been dedicated to providing a professional and scholarly forum centered on the national and international problems associated with drugs, especially illicit drugs. It is a refereed publication with international contributors and subscribers. As a leader in its field, JDI is an instrument widely used by research scholars, public policy analysts, and those involved in the day-to-day struggle against the problem of drug abuse.