Partial gland ablation with high intensity focal ultrasound impact on genito-urinary function and quality of life: our initial experience.

IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY
Canadian Journal of Urology Pub Date : 2024-02-01
Ioana Fugaru, David Bouhadana, Gautier Marcq, Joseph Moryousef, Alexis Rompré-Brodeur, Andrew Meng, Oleg Loutochin, George Loutochin, Maurice Anidjar, Frank Bladou, Rafael Sanchez-Salas
{"title":"Partial gland ablation with high intensity focal ultrasound impact on genito-urinary function and quality of life: our initial experience.","authors":"Ioana Fugaru, David Bouhadana, Gautier Marcq, Joseph Moryousef, Alexis Rompré-Brodeur, Andrew Meng, Oleg Loutochin, George Loutochin, Maurice Anidjar, Frank Bladou, Rafael Sanchez-Salas","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>  Partial gland ablation (PGA) using high intensity focal ultrasound (HIFU) is an alternative to active surveillance for low to intermediate risk localized prostate cancer.  This pilot study assessed quality of life (QoL) outcomes during the implementation of PGA-HIFU at our institution.</p><p><strong>Materials and methods: </strong>  We prospectively enrolled 25 men with a diagnosis of localized low/intermediate risk prostate cancer who elected to undergo PGA-HIFU in a pilot study at our institution between 2013 and 2016.  Patients underwent pre-treatment mpMRI and transrectal ultrasound-guided biopsies.  The primary endpoints were impact on patient-reported functional outcomes (erectile, urinary function, QoL) assessed at 1, 3, 6- and 12-months.</p><p><strong>Results: </strong>  The median age was 64 years old (IQR 59.5-67).  Baseline median International Index of Erectile Function-15 score was 50, which decreased to 18 at 1 month (p < 0.0005), returned to baseline by 3 months and thereafter. International Prostate Symptom Score median at baseline was 8, which worsened to 12 at 1 month (p = 0.0088), and subsequently improved to baseline thereafter.  On the UCLA-Expanded Prostate Cancer Index Composite urinary function, there was a decrease in median score from 92.7 at baseline to 76.0 at 1 month (p < 0.0001), which improved to or above baseline afterwards.  QoL remained similar to baseline at each follow up period as assessed by EQ-5D and the Functional Cancer Therapy-Prostate score.</p><p><strong>Conclusions: </strong>  In this initial cohort of PGA-HIFU men at our institution, patients demonstrated a slight, but transient, deterioration in urinary and erectile function at 1 month prior to normalization.  All QoL metrics showed no impact upon 1 year of follow up post-treatment.</p>","PeriodicalId":56323,"journal":{"name":"Canadian Journal of Urology","volume":"31 1","pages":"11784-11792"},"PeriodicalIF":1.2000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian Journal of Urology","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction:   Partial gland ablation (PGA) using high intensity focal ultrasound (HIFU) is an alternative to active surveillance for low to intermediate risk localized prostate cancer.  This pilot study assessed quality of life (QoL) outcomes during the implementation of PGA-HIFU at our institution.

Materials and methods:   We prospectively enrolled 25 men with a diagnosis of localized low/intermediate risk prostate cancer who elected to undergo PGA-HIFU in a pilot study at our institution between 2013 and 2016.  Patients underwent pre-treatment mpMRI and transrectal ultrasound-guided biopsies.  The primary endpoints were impact on patient-reported functional outcomes (erectile, urinary function, QoL) assessed at 1, 3, 6- and 12-months.

Results:   The median age was 64 years old (IQR 59.5-67).  Baseline median International Index of Erectile Function-15 score was 50, which decreased to 18 at 1 month (p < 0.0005), returned to baseline by 3 months and thereafter. International Prostate Symptom Score median at baseline was 8, which worsened to 12 at 1 month (p = 0.0088), and subsequently improved to baseline thereafter.  On the UCLA-Expanded Prostate Cancer Index Composite urinary function, there was a decrease in median score from 92.7 at baseline to 76.0 at 1 month (p < 0.0001), which improved to or above baseline afterwards.  QoL remained similar to baseline at each follow up period as assessed by EQ-5D and the Functional Cancer Therapy-Prostate score.

Conclusions:   In this initial cohort of PGA-HIFU men at our institution, patients demonstrated a slight, but transient, deterioration in urinary and erectile function at 1 month prior to normalization.  All QoL metrics showed no impact upon 1 year of follow up post-treatment.

用高强度聚焦超声波进行部分腺体消融对泌尿生殖功能和生活质量的影响:我们的初步经验。
导言: 使用高强度聚焦超声(HIFU)进行腺体部分消融(PGA)是中低风险局部前列腺癌积极监测的替代方法。 这项试验性研究评估了我院实施PGA-HIFU期间的生活质量(QoL)结果: 我们前瞻性地招募了 25 名确诊为局部低危/中危前列腺癌的男性患者,他们选择在 2013 年至 2016 年期间接受 PGA-HIFU 治疗。 患者在治疗前接受了 mpMRI 和经直肠超声引导活检。 主要终点是对患者报告的功能结果(勃起、排尿功能、QoL)的影响,评估时间为1、3、6和12个月: 中位年龄为 64 岁(IQR:59.5-67)。 国际勃起功能指数-15 的基线中位数为 50 分,1 个月时降至 18 分(p < 0.0005),3 个月后恢复至基线,此后一直如此。基线时的国际前列腺症状评分中位数为 8 分,1 个月后恶化为 12 分(p = 0.0088),随后又改善至基线。 UCLA 扩增前列腺癌指数综合泌尿功能的中位数从基线时的 92.7 分降至 1 个月时的 76.0 分(p < 0.0001),之后有所改善,达到或超过基线。 根据EQ-5D和前列腺癌功能治疗评分,在每个随访期间,患者的生活质量仍与基线相似: 结论:在我院最初的一批 PGA-HIFU 男性患者中,患者的泌尿和勃起功能在 1 个月后出现轻微但短暂的恶化,随后恢复正常。 在治疗后一年的随访中,所有 QoL 指标均未受到影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Canadian Journal of Urology
Canadian Journal of Urology UROLOGY & NEPHROLOGY-
CiteScore
1.90
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The CJU publishes articles of interest to the field of urology and related specialties who treat urologic diseases.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信