Urine oxygenation predicts COVID-19 risk.

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Clinical and Experimental Nephrology Pub Date : 2024-07-01 Epub Date: 2024-02-24 DOI:10.1007/s10157-023-02456-5
Eisei Noiri, Daisuke Katagiri, Yusuke Asai, Takeshi Sugaya, Katsushi Tokunaga
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引用次数: 0

Abstract

Since February, 2023, the omicron variant has accounted for essentially all new coronavirus infections in Japan. If future infections involve mutant strains with the same level of infectivity and virulence as omicron, the government's basic policy will be to prevent the spread of infection, without compromising socioeconomic activities. Objectives include protecting pregnant women and elderly persons, and focusing on citizens requiring hospitalization and those at risk of serious illness, without imposing new social restrictions. Although the government tries to raise public awareness through education, most people affected by COVID-19 stay at home, and by the time patients become aware of the seriousness of their disease, it has often reached moderate or higher severity. In this review, we discuss why this situation persists even though the disease seems to have become milder with the shift from the delta variant to omicron. We also propose a pathophysiological method to determine the risk of severe illness. This assessment can be made at home in the early stages of COVID-19 infection, using urine analysis. Applicability of this method to drug discovery and development is also discussed.

Abstract Image

尿氧饱和度可预测 COVID-19 风险。
自 2023 年 2 月以来,日本新感染的冠状病毒基本上都是奥米克龙变种。如果今后感染的变异株具有与奥米克龙相同的感染性和毒性,政府的基本政策将是在不影响社会经济活动的前提下防止感染扩散。目标包括保护孕妇和老人,重点关注需要住院治疗的公民和有可能患重病的人,同时不施加新的社会限制。虽然政府试图通过教育来提高公众意识,但大多数 COVID-19 患者都呆在家中,当患者意识到疾病的严重性时,病情往往已达到中度或更严重的程度。在这篇综述中,我们将讨论为什么随着疾病从 delta 变体向 omicron 变体的转变,病情似乎变得更轻了,但这种情况却依然存在。我们还提出了一种确定重症风险的病理生理学方法。在 COVID-19 感染的早期阶段,可以在家通过尿液分析进行评估。我们还讨论了这种方法在药物发现和开发中的适用性。
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来源期刊
Clinical and Experimental Nephrology
Clinical and Experimental Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.10
自引率
4.30%
发文量
135
审稿时长
4-8 weeks
期刊介绍: Clinical and Experimental Nephrology is a peer-reviewed monthly journal, officially published by the Japanese Society of Nephrology (JSN) to provide an international forum for the discussion of research and issues relating to the study of nephrology. Out of respect for the founders of the JSN, the title of this journal uses the term “nephrology,” a word created and brought into use with the establishment of the JSN (Japanese Journal of Nephrology, Vol. 2, No. 1, 1960). The journal publishes articles on all aspects of nephrology, including basic, experimental, and clinical research, so as to share the latest research findings and ideas not only with members of the JSN, but with all researchers who wish to contribute to a better understanding of recent advances in nephrology. The journal is unique in that it introduces to an international readership original reports from Japan and also the clinical standards discussed and agreed by JSN.
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