Sugammadex Use Outside of the Postoperative Setting.

IF 2.3 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Annals of Pharmacotherapy Pub Date : 2024-11-01 Epub Date: 2024-02-22 DOI:10.1177/10600280241232660
Hayley T Gartner, Megan A Rech
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引用次数: 0

Abstract

Background: Sugammadex rapidly reverses the nondepolarizing neuromuscular blocking agents (NMBAs) rocuronium and vecuronium. The role of sugammadex is not well-defined outside of the postoperative setting.

Objective: This study aims to describe sugammadex use outside the postoperative setting for the reversal of nondepolarizing NMBAs.

Methods: This was a single-center, retrospective cohort study conducted in patients who received sugammadex outside of the postoperative setting at an academic medical center between June 2016 and November 2022. The primary outcome was the effect of sugammadex use for rocuronium reversal, defined as any increase in train-of-four (TOF) after sugammadex administration and/or progress note documentation if TOF was unavailable. Secondary outcomes included adverse events and documentation of contraceptive counseling in patients taking hormonal contraceptives with child-bearing ability.

Results: A total of 14 383 patients received sugammadex during the study period. Of those patients, 39 (0.3%) were outside of the postoperative setting for the reversal of rocuronium and included in the study. Twenty-nine (74%) patients had an increase in TOF after sugammadex administration and/or progress note documentation if TOF was unavailable. Ten (26%) patients lacked documentation regarding the effect of sugammadex. No adverse reactions were reported. Three (8%) patients included in the study were of child-bearing ability, and 1 of the 3 patients was counseled on using an alternative method of contraception following sugammadex administration.

Conclusion and relevance: There is a paucity of literature for the use of sugammadex outside of the postoperative setting. This study found that while the use of sugammadex was rare, overall, it was safe and well-tolerated.

术后环境外使用舒格迈司。
背景:舒甘麦可迅速逆转非去极化神经肌肉阻滞剂(NMBA)罗库洛铵和维库洛铵。苏甘麦司在术后以外的作用尚未明确:本研究旨在描述苏甘麦克斯在术后环境之外逆转非去极化 NMBAs 的作用:这是一项单中心、回顾性队列研究,研究对象是2016年6月至2022年11月期间在一家学术医疗中心术后环境外接受舒甘美定治疗的患者。研究的主要结果是使用苏加麦胺进行罗库溴铵逆转的效果,定义为使用苏加麦胺后四肢肌力(TOF)的任何增加,和/或如果无法获得四肢肌力(TOF)的进展记录。次要结果包括不良事件和服用激素避孕药且有生育能力的患者的避孕咨询记录:在研究期间,共有 14 383 名患者接受了舒甘麦注射液治疗。在这些患者中,有 39 例(0.3%)是在术后环境外逆转罗库溴铵而被纳入研究的。29例(74%)患者在服用苏加麦胺后TOF增加,和/或如果没有TOF的进展记录文件。10例(26%)患者缺乏有关舒甘美效果的记录。无不良反应报告。3名(8%)参与研究的患者有生育能力,其中1名患者在服用舒甘麦后接受了使用其他避孕方法的指导:关于术后环境外使用苏麦丁的文献很少。本研究发现,虽然苏甘麦司的使用很少见,但总体而言,其安全性和耐受性良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.70
自引率
0.00%
发文量
166
审稿时长
3-8 weeks
期刊介绍: Annals of Pharmacotherapy (AOP) is a peer-reviewed journal that advances pharmacotherapy throughout the world by publishing high-quality research and review articles to achieve the most desired health outcomes.The articles provide cutting-edge information about the most efficient, safe and cost-effective pharmacotherapy for the treatment and prevention of various illnesses. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 14 days
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