Polymer Vesicles and Lipid Nanoparticles

IF 10.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Annual Review of Materials Research Pub Date : 2024-02-21 DOI:10.1146/annurev-matsci-080222-105636

Yingtong Luo, Alexander B. Cook, Loai K.E.A. Abdelmohsen, Jan C.M. van Hest

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引用次数: 0

Abstract

Polymer vesicles and lipid nanoparticles are supramolecular structures with similar physicochemical properties that are self-assembled from different amphiphilic molecules. Because of their efficient drug encapsulation capability, they are good candidates for drug delivery systems. In recent years, nanoparticles with different compositions, sizes, and morphologies have been applied to the delivery of a wide variety of different therapeutic molecules, such as nucleic acids, proteins, and enzymes; their remarkable chemical versatility allows for customization to specific biological applications. In this review, design approaches for polymer vesicles and lipid nanoparticles are summarized with representative examples in terms of their physicochemical properties (size, shape, and mechanical features), preparation strategies (film rehydration, solvent switch, and nanoprecipitation), and applications (with a focus on diagnosis, imaging, and RNA-based therapy). Finally, the challenges limiting the transition from laboratory to clinical application and future perspectives are discussed.Expected final online publication date for the Annual Review of Materials Research, Volume 54 is July 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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聚合物囊泡和脂质纳米颗粒

聚合物囊泡和脂质纳米粒子是由不同的两亲性分子自组装而成的超分子结构，具有相似的物理化学性质。由于它们具有高效的药物包裹能力，因此是药物输送系统的良好候选材料。近年来，具有不同组成、大小和形态的纳米颗粒已被应用于多种不同治疗分子（如核酸、蛋白质和酶）的给药；它们显著的化学多功能性使其可定制用于特定的生物应用。在这篇综述中，我们通过具有代表性的实例，从理化特性（尺寸、形状和机械特征）、制备策略（薄膜再水化、溶剂转换和纳米沉淀）和应用（重点是诊断、成像和基于 RNA 的治疗）等方面总结了聚合物囊泡和脂质纳米颗粒的设计方法。最后，讨论了限制从实验室到临床应用过渡的挑战和未来展望。《材料研究年度综述》第 54 卷的最终在线出版日期预计为 2024 年 7 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Materials Research 工程技术-材料科学：综合

CiteScore

17.70

自引率

1.00%

发文量

期刊介绍： The Annual Review of Materials Research, published since 1971, is a journal that covers significant developments in the field of materials research. It includes original methodologies, materials phenomena, material systems, and special keynote topics. The current volume of the journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license. The journal defines its scope as encompassing significant developments in materials science, including methodologies for studying materials and materials phenomena. It is indexed and abstracted in various databases, such as Scopus, Science Citation Index Expanded, Civil Engineering Abstracts, INSPEC, and Academic Search, among others.