Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies

IF 11.5 2区生物学 Q1 GENETICS & HEREDITY

Genomics, Proteomics & Bioinformatics Pub Date : 2024-01-10 DOI:10.1093/gpbjnl/qzad005

Liwen Xiao, Zhenqiang Zuo, Fangqing Zhao

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Abstract The microbiome plays a critical role in the process of conception and the outcomes of pregnancy. Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications, which significantly impact maternal and fetal health. Recent studies have associated the microbiome in the female reproductive tract (FRT) with assisted reproductive technology (ART) outcomes, and restoring microbiome balance has been shown to improve fertility in infertile couples. This review provides an overview of the role of the microbiome in female reproductive health, including its implications for pregnancy outcomes and ARTs. Additionally, recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized. A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health. Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.

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女性生殖健康中的微生物组：对生育和辅助生殖技术的影响

摘要微生物组在受孕过程和妊娠结果中起着至关重要的作用。育龄妇女体内微生物组平衡的破坏会导致各种妊娠并发症，从而严重影响母体和胎儿的健康。最近的研究表明，女性生殖道（FRT）中的微生物组与辅助生殖技术（ART）的结果有关，恢复微生物组的平衡可提高不孕夫妇的生育能力。本综述概述了微生物组在女性生殖健康中的作用，包括其对妊娠结局和辅助生殖技术的影响。此外，还总结了使用微生物生物标志物作为妊娠紊乱指标的最新进展。全面了解妊娠前和妊娠期间微生物组的特征及其对生殖健康的影响将极大地促进孕产妇和胎儿的健康。这些知识还有助于开发抗逆转录病毒疗法和基于微生物组的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genomics, Proteomics & Bioinformatics Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

14.30

自引率

4.20%

发文量

844

审稿时长

61 days

期刊介绍： Genomics, Proteomics and Bioinformatics (GPB) is the official journal of the Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation and Genetics Society of China. It aims to disseminate new developments in the field of omics and bioinformatics, publish high-quality discoveries quickly, and promote open access and online publication. GPB welcomes submissions in all areas of life science, biology, and biomedicine, with a focus on large data acquisition, analysis, and curation. Manuscripts covering omics and related bioinformatics topics are particularly encouraged. GPB is indexed/abstracted by PubMed/MEDLINE, PubMed Central, Scopus, BIOSIS Previews, Chemical Abstracts, CSCD, among others.