Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro

IF 1.3 4区医学 Q4 PHARMACOLOGY & PHARMACY

Xenobiotica Pub Date : 2024-02-22 DOI:10.1080/00498254.2024.2321969

Congrong Wang, Naixiang Zhou, Mingcui Li, Haixia Chen

引用次数: 0

Abstract

1. To assess the effect of Rehmannioside A on CYP450s activity and to estimate its inhibitory properties.2. The effect of Rehmannioside A on the activity of major CYP450s in human liver microsomes ...

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地黄甙 A 在体外可抑制 CYP3A4、2C9 和 2D6 的活性

1.评估地黄甙 A 对 CYP450s 活性的影响并估计其抑制特性。 2. 地黄甙 A 对人肝脏微粒体中主要 CYP450s 活性的影响 ...

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来源期刊

Xenobiotica 医学-毒理学

CiteScore

3.80

自引率

5.60%

发文量

审稿时长

2 months

期刊介绍： Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology