Genetic and clinical study of myeloperoxidase's association with coronary artery disease

The Egyptian Heart Journal Pub Date : 2024-02-21 DOI:10.1186/s43044-024-00457-7

Lina N. Adam, Omar A. M. Al-Habib, Ashur Y. Oraha, Mudhir S. Shekha

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Abstract

Unraveling myeloperoxidase’s (MPO) correlation with coronary artery disease (CAD) and genetic variations, this study seeks to enhance diagnostic precision and therapeutic strategies. CAD patients were found to be older and more male than controls. Several clinical parameters, including glucose, total bilirubin, alkaline phosphatase, creatinine, and troponin levels, showed significant variations. Moreover, CAD patients had lower red cell distribution width (RDW%) and mean platelet volume (MPV) than controls. Serum MPO levels did not differ significantly between CAD patients and controls, and no correlation was found with other clinical parameters except for glucose, creatinine, and total bilirubin. The data suggest that serum MPO levels are not substantially related to CAD patients, as indicated by lower MPO levels in CAD patients compared to controls. While highlighting the potential of MPV and RDW% as predictors of severe atherosclerosis in CAD. Further research is needed to validate the diagnostic and prognostic value of RDW%, MPV, and MPO levels in CAD. Trial registration: 15092021-9-12. Registered 15 September 2021.

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髓过氧化物酶与冠心病关系的遗传和临床研究

本研究揭示了髓过氧化物酶（MPO）与冠状动脉疾病（CAD）和基因变异的相关性，旨在提高诊断的精确性和治疗策略。研究发现，与对照组相比，CAD 患者年龄更大，男性更多。一些临床参数，包括血糖、总胆红素、碱性磷酸酶、肌酐和肌钙蛋白水平，都出现了显著变化。此外，与对照组相比，CAD 患者的红细胞分布宽度（RDW%）和平均血小板体积（MPV）较低。除血糖、肌酐和总胆红素外，血清 MPO 水平与其他临床指标无明显相关性。数据表明，与对照组相比，CAD 患者的 MPO 水平较低，这表明血清 MPO 水平与 CAD 患者没有实质性关系。这凸显了 MPV 和 RDW% 作为 CAD 严重动脉粥样硬化预测指标的潜力。要验证 RDW%、MPV 和 MPO 水平在 CAD 中的诊断和预后价值，还需要进一步的研究。试验注册：15092021-9-12.注册日期：2021 年 9 月 15 日。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Egyptian Heart Journal

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