{"title":"Phosphoinositide turnover and calcium ion mobilization in receptor activation.","authors":"Y Nozawa","doi":"10.1007/BF03160356","DOIUrl":null,"url":null,"abstract":"<p><p>Ca2+ is now recognized to play a central role in the cellular signal transduction system. The hydrolysis of inositol phospholipids is an initial and essential event in Ca2+-mobilizing receptor activation. Phospholipase C cleaves phosphatidylinositol 4,5-bisphosphate to yield two intracellular messengers: inositol 1,4,5-trisphosphate that mobilizes Ca2+ from intracellular storage sites, and 1,2-diacylglycerol that activates protein kinase C. In this chapter, I will describe the functional role of phosphoinositide breakdown during receptor activation and the regulatory mechanism of phospholipase C.</p>","PeriodicalId":77753,"journal":{"name":"Neurochemical pathology","volume":"9 ","pages":"89-108"},"PeriodicalIF":0.0000,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF03160356","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF03160356","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Ca2+ is now recognized to play a central role in the cellular signal transduction system. The hydrolysis of inositol phospholipids is an initial and essential event in Ca2+-mobilizing receptor activation. Phospholipase C cleaves phosphatidylinositol 4,5-bisphosphate to yield two intracellular messengers: inositol 1,4,5-trisphosphate that mobilizes Ca2+ from intracellular storage sites, and 1,2-diacylglycerol that activates protein kinase C. In this chapter, I will describe the functional role of phosphoinositide breakdown during receptor activation and the regulatory mechanism of phospholipase C.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
