Ke Liu, Pei Zhang, Ling Zhou, Lin Han, Linhua Zhao, Xiaotong Yu
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引用次数: 0
Abstract
Autoimmune thyroiditis (AIT), also known as Hashimoto's thyroiditis (HT), is an autoimmune disease that is characterised by elevated thyroid-specific antibody titres. The incidence of AIT is increasing year over year, making it urgent to establish a suitable animal model for this condition, in order to better explore its pathogenesis and potential pharmaceutical mechanisms for treatment. Owing to a lack of basic research on this disease, problems such as disparate modelling methods with unclear and varying success rates make it difficult for researchers to obtain effective information on AIT in the short term. This report summarises and analyzes the current literature on AIT and combines actual operability to explain the selection and specific implementation processes behind the uses of different modelling approaches, to provide a better overall understanding of autoimmune thyroid diseases.
自身免疫性甲状腺炎（AIT）又称桥本氏甲状腺炎（HT），是一种以甲状腺特异性抗体滴度升高为特征的自身免疫性疾病。AIT 的发病率逐年上升，因此迫切需要建立一种合适的动物模型，以便更好地探索其发病机制和潜在的药物治疗机制。由于缺乏对该疾病的基础研究，建模方法不统一、成功率不明确且参差不齐等问题使得研究人员很难在短期内获得有关 AIT 的有效信息。本报告对目前有关AIT的文献进行了总结和分析，并结合实际可操作性，阐述了不同建模方法使用背后的选择和具体实施过程，以期更好地全面了解自身免疫性甲状腺疾病。
期刊介绍：
Autoimmunity is an international, peer reviewed journal that publishes articles on cell and molecular immunology, immunogenetics, molecular biology and autoimmunity. Current understanding of immunity and autoimmunity is being furthered by the progress in new molecular sciences that has recently been little short of spectacular. In addition to the basic elements and mechanisms of the immune system, Autoimmunity is interested in the cellular and molecular processes associated with systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, type I diabetes, multiple sclerosis and other systemic and organ-specific autoimmune disorders. The journal reflects the immunology areas where scientific progress is most rapid. It is a valuable tool to basic and translational researchers in cell biology, genetics and molecular biology of immunity and autoimmunity.
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