Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial.

IF 3.2 Q1 PEDIATRICS
Clinical and Experimental Pediatrics Pub Date : 2024-04-01 Epub Date: 2024-02-19 DOI:10.3345/cep.2023.01340
Deldar Morad Abdulah, Saad Jbraeil Sulaiman, Zaid Waad Ahmed
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引用次数: 0

Abstract

Background: Findings are conflicting regarding the effect of zinc supplementation on disease severity in children with acute gastroenteritis.

Purpose: To examine the effects of probiotics and zinc on the clinical outcomes of infants and children with acute infectious diarrhea.

Methods: In this randomized controlled trial, children with mild or moderate to severe acute gastroenteritis in the Kurdistan Region from November 2021 to June 2022 were diagnosed clinically and randomly assigned to the experimental or control group. The experimental group (n=50) received probiotics and zinc, whereas the control group (n=51) received probiotics alone for 1 week. The product contained live Bifidobacterium infantis, Lactobacillus paracasei, and Lactobacillus rhamnosus (10×106 colony-forming units/day for 7 days). Zinc syrup was administered to the probiotic plus zinc group. Each 5 mL of syrup contained 15 mg of zinc sulfate. Dehydration and disease severity in both groups were measured using the Clinical Dehydration Scale and the Modified Vesikari Scale, respectively. An illness episode was defined as an episode of gastroenteritis with a total score of ≥9 on the Modified Vesikari Scale (range, 0-20).

Results: The probiotic and probiotic plus zinc groups were similar in age (1.79 years vs. 1.69 years, respectively; P= 0.645), sex (male/female ratio: 1.43 and 1.0, respectively; P=0.373), and medical characteristics. The groups had similar mean dehydration and disease severity scores and a similar incidence of dehydration recovery (some dehydration, 3.92% and 4.00%, respectively; P=1.000), and recovery from mild gastroenteritis (0.0% and 2.0%, respectively; P=0.495) at 2 weeks. Significant decreases in mean dehydration severity and disease severity score (1.80 to 0 and 6.66 to 0, respectively; P<0.001) and the development of dehydration (some dehydration, from 94.0% to 4.0%; P<0.001) from baseline to 2 weeks were noted in the probiotics plus zinc group. The probiotics group responded similarly. The development of mild gastroenteritis was significantly reduced from baseline to 2 weeks (90.2% to 0% and 78.0% to 2.0% in the probiotics and probiotics plus zinc groups, respectively; P<0.0001). The probiotics plus zinc group had a shorter mean recovery time (1.34 days vs. 2.00 days, respectively; P<0.001).

Conclusion: Taking probiotics plus zinc did not significantly affect disease severity in children with gastroenteritis at 2 weeks. However, the probiotics plus zinc group recovered more quickly than the probiotics group.

益生菌加锌对急性感染性腹泻婴幼儿临床疗效的影响:随机对照试验。
背景:关于补锌对急性肠胃炎患儿疾病严重程度的影响,研究结果相互矛盾:目的:研究益生菌和锌对急性感染性腹泻婴幼儿临床疗效的影响:在这项随机对照试验中,2021年11月至2022年6月期间库尔德斯坦地区患有轻度或中重度急性肠胃炎的儿童经临床诊断后被随机分配到实验组或对照组。实验组(50 人)服用益生菌和锌,而对照组(51 人)仅服用益生菌 1 周。产品中含有活的婴儿双歧杆菌、副干酪乳杆菌和鼠李糖乳杆菌(10 × 106 菌落总数单位/天,连续 7 天)。益生菌加锌组使用锌糖浆。每 5 毫升糖浆含有 15 毫克硫酸锌。两组的脱水和疾病严重程度分别采用临床脱水量表和改良维西卡里量表进行测量。改良维西卡里量表的总分≥9分(范围为0-20分)即为一次肠胃炎发作:益生菌组和益生菌加锌组在年龄(分别为 1.79 岁和 1.69 岁;P=0.645)、性别(男女比例分别为 1.43 和 1.0;P=0.373)和医疗特征方面相似。两组的平均脱水和疾病严重程度评分相似,两周后脱水恢复(部分脱水,分别为 3.92% 和 4.00%;P=1.000)和轻度肠胃炎恢复(分别为 0.0% 和 2.0%;P=0.495)的发生率相似。平均脱水严重程度和疾病严重程度评分显著下降(分别为 1.80 分至 0 分和 6.66 分至 0 分;P=0.495):服用益生菌加锌对肠胃炎患儿两周后的疾病严重程度没有明显影响。不过,益生菌加锌组比益生菌组恢复得更快。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.00
自引率
2.40%
发文量
88
审稿时长
60 weeks
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