Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report.

IF 3 4区医学 Q2 NEUROSCIENCES

Purinergic Signalling Pub Date : 2024-10-01 Epub Date: 2024-02-20 DOI:10.1007/s11302-024-09994-x

Luke Tattersall, Elena Adinolfi, Luca Antonioli, Ankita Agrawal

引用次数: 0

Abstract

PRESTO was established in 2022 and is a concerted effort by leading European experts in the field of P2XRs and extracellular ATP to promote and advance the transition to the clinic of P2XR-targeting therapies. Following the inaugural meeting in Ferrara which set the foundations of the action and generated interest from many groups and institutes, the second meeting covered the preclinical and clinical aspects of P2XRs as a common route in different diseases, recognising the multidisciplinary and collaborative approach required for a number of medical conditions.

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P2X 受体作为不同疾病共同途径的临床前和临床方面：会议报告。

PRESTO 成立于 2022 年，是欧洲 P2XR 和细胞外 ATP 领域顶尖专家的共同努力成果，旨在促进和推动 P2XR 靶向疗法向临床过渡。在费拉拉举行的首次会议为这一行动奠定了基础，并引起了许多团体和机构的兴趣，随后举行的第二次会议涵盖了 P2XRs 作为不同疾病常见途径的临床前和临床方面的问题，并认识到多种医疗条件所需的多学科协作方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Purinergic Signalling 医学-神经科学

CiteScore

6.60

自引率

17.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.